Bladen Jackson, Nam Hyuck-Jin, Phadnis Nitin
School of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
bioRxiv. 2024 May 14:2024.05.10.593569. doi: 10.1101/2024.05.10.593569.
Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, few examples directly linking meiotic drive to hybrid sterility. Here, we report that the chromosome of , which causes X-chromosome drive within the USA subspecies, causes near complete male sterility when moved into the genetic background of the Bogota subspecies. In addition, we show that this new form of sterility is genetically distinct from the sterility of F1 hybrid males in crosses between USA males and Bogota females. Our observations provide a tractable study system where non-cryptic drive within species is transformed into strong hybrid sterility between very young subspecies.
杂种雄性不育是最近隔离的种群之间进化最快的内在生殖障碍之一。对杂种雄性不育进化的一个主要解释涉及雄性生殖系中与减数分裂驱动因子的基因组冲突。然而，很少有例子直接将减数分裂驱动与杂种不育联系起来。在这里，我们报告说，在美国亚种中导致X染色体驱动的 染色体，当转移到波哥大亚种的遗传背景中时，会导致近乎完全的雄性不育。此外，我们表明这种新的不育形式在遗传上与美国雄性和波哥大雌性杂交的F1杂种雄性的不育不同。我们的观察提供了一个易于处理的研究系统，其中物种内的非隐性驱动转化为非常年轻的亚种之间强烈的杂种不育。
