Rudolph Jacqueline E, Calkins Keri L, Zhang Xueer, Zhou Yiyi, Xu Xiaoqiang, Wentz Eryka L, Joshu Corinne E, Lau Bryan
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Mathematica, Ann Arbor, MI.
medRxiv. 2024 May 13:2024.05.13.24307278. doi: 10.1101/2024.05.13.24307278.
Disparities in HIV care by socioeconomic status, place of residence, and race/ethnicity prevent progress toward epidemic control. No study has comprehensively characterized the HIV care cascade among people with HIV enrolled in Medicaid - an insurance source for low-income individuals in the US. We analyzed data from 246,127 people with HIV enrolled in Medicaid 2001-2015, aged 18-64, living in 14 US states. We estimated monthly prevalence of four steps of the care cascade: retained in care/adherent to ART; retained/not adherent; not retained/adherent; not retained/not adherent. Beneficiaries were retained in care if they had an outpatient care encounter every six months. Adherence was based on medication possession ratio. We estimated prevalence using a non-parametric multi-state approach, accounting for death as a competing event and for Medicaid disenrollment using inverse probability of censoring weights. Across 2001-2015, the proportion of beneficiaries with HIV who were retained/ART adherent increased, overall and in all subgroups. By 2015, approximately half of beneficiaries were retained in care, and 42% of beneficiaries were ART adherent. We saw meaningful differences by race/ethnicity and region. Our work highlights an important disparity in the HIV care cascade by insurance status during this time period.
社会经济地位、居住地点以及种族/族裔方面的差异阻碍了艾滋病疫情防控工作的进展。尚无研究全面描述参加医疗补助计划(美国为低收入人群提供的一种保险)的艾滋病病毒感染者的艾滋病护理流程。我们分析了2001年至2015年期间参加医疗补助计划、年龄在18至64岁之间、居住在美国14个州的246,127名艾滋病病毒感染者的数据。我们估计了护理流程四个阶段的月度流行率:接受护理/坚持抗逆转录病毒治疗;接受护理/未坚持;未接受护理/坚持;未接受护理/未坚持。如果受益人每六个月有一次门诊护理就诊,则被视为接受护理。坚持治疗基于药物持有率。我们使用非参数多状态方法估计流行率,将死亡作为竞争事件,并使用逆概率删失权重来考虑医疗补助计划退保情况。在2001年至2015年期间,总体以及所有亚组中,接受护理/坚持抗逆转录病毒治疗的艾滋病病毒感染受益人的比例均有所增加。到2015年,约一半的受益人接受了护理,42%的受益人坚持抗逆转录病毒治疗。我们发现种族/族裔和地区存在显著差异。我们的研究突出了这一时期保险状况在艾滋病护理流程方面的一个重要差异。