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2001-2015 年,医疗补助受益人群中艾滋病毒感染者的治疗保留率和抗逆转录病毒治疗依从性。

Retention in care and antiretroviral therapy adherence among Medicaid beneficiaries with HIV, 2001-2015.

机构信息

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Mathematica, Ann Arbor, MI, USA.

出版信息

AIDS Care. 2024 Nov;36(11):1668-1680. doi: 10.1080/09540121.2024.2383901. Epub 2024 Jul 30.

DOI:10.1080/09540121.2024.2383901
PMID:39078934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11511646/
Abstract

Disparities in HIV care by socioeconomic status, place of residence, and race/ethnicity prevent progress toward epidemic control. No study has comprehensively characterized the HIV care cascade among people with HIV enrolled in Medicaid - an insurance source for low-income individuals in the US. We analyzed data from 246,127 people with HIV enrolled in Medicaid 2001-2015, aged 18-64, living in 14 US states. We estimated the monthly prevalence of four steps of the care cascade: retained in care/adherent to ART; retained/not adherent; not retained/adherent; not retained/not adherent. Beneficiaries were retained in care if they had an outpatient care encounter every six months. Adherence was based on medication possession ratio. We estimated prevalence using a non-parametric multi-state approach, accounting for death as a competing event and for Medicaid disenrollment using inverse probability of censoring weights. Across 2001-2015, the proportion of beneficiaries with HIV who were retained/ART adherent increased, overall and in all subgroups. By 2015, approximately half of beneficiaries were retained in care, and 42% of beneficiaries were ART adherent. We saw meaningful differences by race/ethnicity and region. Our work highlights an important disparity in the HIV care cascade by insurance status during this time period.

摘要

由于社会经济地位、居住地和种族/民族的差异,艾滋病毒护理方面的差距阻碍了艾滋病流行的控制。没有研究全面描述了参加医疗补助计划(美国低收入人群的保险来源)的艾滋病毒感染者的艾滋病毒护理级联。我们分析了 2001-2015 年期间参加医疗补助计划的 246127 名年龄在 18-64 岁之间的艾滋病毒感染者的数据,他们居住在美国 14 个州。我们估计了护理级联的四个步骤的每月流行率:在护理中保留/对 ART 保持依从性;保留/不依从;未保留/依从;未保留/不依从。如果患者每六个月有一次门诊护理就诊,就可以在护理中保留。依从性基于药物占有比。我们使用非参数多状态方法估计流行率,将死亡视为竞争事件,并使用反概率 censoring 权重来考虑医疗补助计划退出的情况。在 2001-2015 年期间,保留/ART 依从性的艾滋病毒感染者的比例总体上和所有亚组中都有所增加。到 2015 年,大约一半的患者保留在护理中,42%的患者接受了 ART 治疗。我们看到了种族/民族和地区之间的显著差异。我们的工作突出了在此期间保险状况对艾滋病毒护理级联的一个重要差异。

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本文引用的文献

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Comparing Cancer Incidence in an Observational Cohort of Medicaid Beneficiaries With and Without HIV, 2001-2015.比较 2001-2015 年有和没有艾滋病毒的医疗补助受益人的观察队列中的癌症发病率。
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AIDS Patient Care STDS. 2020 Nov;34(11):461-469. doi: 10.1089/apc.2020.0145.
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One Size Fits (n)One: The Influence of Sex, Age, and Sexual Human Immunodeficiency Virus (HIV) Acquisition Risk on Racial/Ethnic Disparities in the HIV Care Continuum in the United States.一刀切:性别、年龄和性人类免疫缺陷病毒(HIV)感染风险对美国 HIV 护理连续体中种族/民族差异的影响。
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