α1-抗胰蛋白酶-匹兹堡型：一种强效的人血浆因子XIa、激肽释放酶和因子XIIf抑制剂。
Alpha 1-antitrypsin-Pittsburgh: a potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.
作者信息
Scott C F, Carrell R W, Glaser C B, Lewis J H, Colman R W
出版信息
Trans Assoc Am Physicians. 1985;98:344-51.
PMID:3879844
Abstract
AT-P is a potent inhibitor of factor XIa. It has a greater affinity for factor XIa (5.1 X 10(5) M-1 sec-1), than it does for thrombin (3.1 X 10(5) M-1 sec-1). This recently cloned protein may be clinically valuable in the management of disorders involving activation of the contact system of plasma proteolysis.
摘要
抗凝血酶 - P是因子Xla的一种强效抑制剂。它对因子Xla的亲和力（5.1×10⁵ M⁻¹秒⁻¹）高于对凝血酶的亲和力（3.1×10⁵ M⁻¹秒⁻¹）。这种最近克隆出的蛋白质在涉及血浆蛋白水解接触系统激活的疾病管理中可能具有临床价值。
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