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具有高度侵袭性的黑素瘤细胞的慢周期亚群。

A slow-cycling subpopulation of melanoma cells with highly invasive properties.

机构信息

Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.

Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria.

出版信息

Oncogene. 2018 Jan 18;37(3):302-312. doi: 10.1038/onc.2017.341. Epub 2017 Sep 18.

DOI:10.1038/onc.2017.341
PMID:28925403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5799768/
Abstract

Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. We demonstrate through live imaging that LRC are leaving the primary tumor mass at a very early stage and disseminate to peripheral organs. Through global proteome analyses, we identified the secreted protein SerpinE2/protease nexin-1 as causative for the highly invasive potential of LRC in melanomas.

摘要

黑色素瘤是一种具有不同亚群的异质性肿瘤，不同亚群的增殖速度不同。先前在黑色素瘤中鉴定出了慢循环细胞，但尚未完全进行生物学特征描述。我们使用标记保留方法鉴定出了一个具有强侵袭性的慢循环细胞亚群，即标记保留细胞（LRC）。通过实时成像，我们证明 LRC 很早就从原发性肿瘤中离开，并扩散到周围器官。通过全蛋白质组分析，我们鉴定出分泌蛋白 SerpinE2/蛋白酶素 1 是导致黑色素瘤中 LRC 具有高侵袭性的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/2535c26e7fac/onc2017341f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/af989e35cf66/onc2017341f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/d03929933b48/onc2017341f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/360fbaf3cde1/onc2017341f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/d1cd0f1fdf0a/onc2017341f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/2535c26e7fac/onc2017341f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/af989e35cf66/onc2017341f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/d03929933b48/onc2017341f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/360fbaf3cde1/onc2017341f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/d1cd0f1fdf0a/onc2017341f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4516/5799768/2535c26e7fac/onc2017341f5.jpg

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