Han Woo Yeon, Lee Young Soon, Han Hyun Ho
From the Department of Plastic and Reconstructive Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Plast Reconstr Surg Glob Open. 2024 May 20;12(5):e5813. doi: 10.1097/GOX.0000000000005813. eCollection 2024 May.
Many individuals hold an interest in aesthetic appeal, with one aspect of physical attractiveness being the alluring contour of the lower leg. Utilizing botulinum toxin A (BTX-A) injections offers several advantages, including a short procedure time, low pain, and a speedy recovery. With a demand for high-level evidence regarding the effectiveness of BTX-A injections for correction of lower leg contour, we evaluated the safety and efficacy of BTX-A injection for improvement of gastrocnemius muscle hypertrophy.
We conducted a prospective, randomized, and controlled clinical trial to evaluate whether the injection of BTX-A into the gastrocnemius muscle could decrease muscular hypertrophy. The patients were randomized into a low-dose injection (60 units) group and a high-dose injection group (100 units) for each leg. Demographics, clinical outcome, and satisfaction score were compared between the two groups.
A total of 20 patients and 40 legs were enrolled in this study. Clinical and surgical demographics were similar between the two groups. BTX-A injection showed a significant decrease in the circumference of the calf after 8 weeks (preinjection: 36.35 ± 0.63 cm versus postinjection: 35.87 ± 0.61 cm; = 0.03). However, no significant difference was observed between the low- and the high-dose group (-0.52 ± 0.74 cm versus -0.44 ± 1.04 cm, = 0.78).
BTX-A injection can be a good noninvasive method for the correction of hypertrophic gastrocnemius muscles. This study supports the use of BTX-A injections in patients unsatisfied with lower leg hypertrophy.
许多人对审美有兴趣，小腿诱人的轮廓是身体吸引力的一个方面。注射A型肉毒杆菌毒素（BTX-A）有几个优点，包括手术时间短、疼痛轻和恢复快。鉴于对BTX-A注射改善小腿轮廓有效性的高级别证据有需求，我们评估了BTX-A注射改善腓肠肌肥大的安全性和有效性。
我们进行了一项前瞻性、随机对照临床试验，以评估向腓肠肌注射BTX-A是否能减少肌肉肥大。患者被随机分为低剂量注射（60单位）组和高剂量注射组（100单位），每组每条腿。比较两组的人口统计学、临床结果和满意度评分。
本研究共纳入20例患者和40条腿。两组的临床和手术人口统计学特征相似。8周后，BTX-A注射使小腿周长显著减小（注射前：36.35±0.63厘米，注射后：35.87±0.61厘米；P=0.03）。然而，低剂量组和高剂量组之间未观察到显著差异（-0.52±0.74厘米对-0.44±1.04厘米，P=0.78）。
BTX-A注射可以是一种矫正腓肠肌肥大的良好非侵入性方法。本研究支持对不满意小腿肥大的患者使用BTX-A注射。
