Adesina Oluwagbemiga Ayomiposi, Ogamba Chibuzor Franklin, Osibogun Akin
Faculty of Clinical Science, College of Medicine of the University of Lagos, Nigeria.
Department of Internal Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
Niger Med J. 2022 Sep 10;63(1):50-58. doi: 10.60787/NMJ-63-1-94. eCollection 2022 Jan-Feb.
Strategies involved in the prevention and management of sickle cell disease include premarital genotype screening and counselling as well as efforts at increasing the knowledge of the population about the condition.
This is a cross-sectional descriptive study which assessed the knowledge of sickle cell disease and premarital genotype screening, attitudes towards screening and factors associated with uptake of premarital genotype screening among 326 final year students at the University of Ibadan, Oyo State, Nigeria.
Respondents were within the age range of 18-24 with a mean age of 23. Majority of the respondents had AA genotype (68.71%). Only 15.95% of the respondents had good knowledge of sickle cell disease. Mean knowledge score was 14 out of 26 with a standard deviation of 4.31. 75.77% of the respondents had good knowledge of premarital genotype screening. 76.07% of the respondents had good attitudes to premarital genotype screening. Mean attitude score was 9.5 out of 12 with a standard deviation of 2.15. Respondents' current level of study (P=0.000) and marital status (P=0.042) were significantly associated with knowledge of sickle cell disease. There was significant association between knowledge of sickle cell disease and knowledge of premarital genotype screening (Fisher's P= 0.000). Knowledge of premarital genotype screening was significantly associated with respondents' current level of study (P=0.004) and attitudes to premarital genotype screening (Fisher's P= 0.000).
Significant knowledge gaps were identified in the study population. There is need for continuous assessment of knowledge gaps and educational intervention to decrease the incidence of sickle cell disease.
镰状细胞病的预防和管理策略包括婚前基因分型筛查与咨询，以及提高公众对该病的认识。
这是一项横断面描述性研究，评估了尼日利亚奥约州伊巴丹大学326名 final year 学生对镰状细胞病和婚前基因分型筛查的了解、对筛查的态度以及与接受婚前基因分型筛查相关的因素。
受访者年龄在18 - 24岁之间，平均年龄为23岁。大多数受访者的基因型为AA（68.71%）。只有15.95%的受访者对镰状细胞病有良好的了解。知识得分平均为26分中的14分，标准差为4.31。75.77%的受访者对婚前基因分型筛查有良好的了解。76.07%的受访者对婚前基因分型筛查持积极态度。态度得分平均为12分中的9.5分，标准差为2.15。受访者当前的学习水平（P = 0.000）和婚姻状况（P = 0.042）与镰状细胞病知识显著相关。镰状细胞病知识与婚前基因分型筛查知识之间存在显著关联（费舍尔P值 = 0.000）。婚前基因分型筛查知识与受访者当前的学习水平（P = 0.004）和对婚前基因分型筛查的态度（费舍尔P值 = 0.000）显著相关。
研究人群中存在明显的知识差距。需要持续评估知识差距并进行教育干预，以降低镰状细胞病的发病率。
