Babu Prasath N, Selvaraj J
Department of Veterinary Pathology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu, Thanjavur, Tamil Nadu, India.
Iran J Vet Res. 2023;24(4):357-364. doi: 10.22099/IJVR.2023.47422.6862.
The paper describes the first documentary evidence of intestinal histoplasmosis in Indian goats.
A goat flock in delta region of Tamil Nadu with a report of mortality of eight animals with the history of inappetence, constipation, tenesmus and hematochezia. Three goat carcasses were presented for necropsy.
FINDINGS/TREATMENT AND OUTCOME: Postmortem examination showed mesenteric lymphadenomegaly with greyish yellow viscous contents. Ileum contained scattered dark brownish tubular concretions inside the lumen. Colon and caecum had scattered firm serosal and mucosal nodules with caseous exudate. Lumen contained viscous haemorrhagic content. Mucosa of the colon showed numerous tiny ulcers. Urinary bladder serosa showed a focal firm nodule with caseous exudate and irregular firm mass. Microscopically, lung revealed oval inclusions with clear halo in pulmonary macrophages. Caecum and colon showed ulcers with necrotic core. Necrotic border showed multinucleated giant cells and oval bodies with clear halo. Mesenteric lymph node and urinary bladder revealed pyogranulomatous inflammation with aggregation of macrophages filled with numerous tiny inclusions. Periodic acid-Schiff and Grocott's methanamine silver staining techniques and morphological features of the inclusion confirmed it as . The case showed a resemblance with human colonic histoplasmosis.
This report documents the first incidence of intestinal histoplasmosis in goats. Interestingly, the intestinal form of histoplasmosis is considered to be common in humans and it showed similarity with human disease in goats based on the gross and microscopic lesions.
本文描述了印度山羊肠道组织胞浆菌病的首个文献证据。
泰米尔纳德邦三角洲地区的一群山羊，有8只动物死亡报告，伴有食欲不振、便秘、里急后重和便血病史。送来3具山羊尸体进行尸检。
检查结果/治疗及结果：尸检显示肠系膜淋巴结肿大，内含灰黄色粘性内容物。回肠腔内有散在的深褐色管状结石。结肠和盲肠有散在的坚实浆膜和粘膜结节，伴有干酪样渗出物。肠腔内有粘性出血性内容物。结肠粘膜有许多微小溃疡。膀胱浆膜有一个局灶性坚实结节，伴有干酪样渗出物和不规则坚实肿块。显微镜下，肺脏在肺巨噬细胞中可见有清晰晕圈的椭圆形包涵体。盲肠和结肠有坏死核心的溃疡。坏死边缘可见多核巨细胞和有清晰晕圈的椭圆形小体。肠系膜淋巴结和膀胱显示脓性肉芽肿性炎症，巨噬细胞聚集，充满许多微小包涵体。过碘酸希夫染色和格罗科特甲胺银染色技术以及包涵体的形态特征证实其为……。该病例与人类结肠组织胞浆菌病相似。
本报告记录了山羊肠道组织胞浆菌病的首例发病情况。有趣的是，组织胞浆菌病的肠道形式在人类中被认为很常见，并且基于大体和微观病变，它在山羊中与人类疾病表现出相似性。
