Cong Zhengtu, Zhang Liguo, Li Min, Tao Jiangang, Ma Hui
Hainan Provincial Institute of Mental Health, Hainan Provincial Anning Hospital, Hainan, China.
Department of Psychiatry, The Third Hospital of Heilongjiang Province, Heilongjiang, China.
Alpha Psychiatry. 2024 Jan 1;25(1):63-67. doi: 10.5152/alphapsychiatry.2024.231374. eCollection 2024 Jan.
Stathmin 1 (Stmn1) is a neuronal growth-associated protein which was found to be involved in fear processing both in animals and humans. Moreover, it has been demonstrated that 2 single nucleotide polymorphisms (SNPs) of the gene (rs182455 and rs213641) significantly impacted individual fear and anxiety responses in German. However, there have been no reports on the correlation between SNPs and anxiety in Chinese. The present study thus aimed to explore such correlation.
A sample of 567 healthy Han Chinese adults were genotyped for the SNP, namely rs182455, using polymerase chain reaction and restriction fragment length polymorphism analysis. Anxiety was assessed by the Chinese version of 40-item State-Trait Anxiety Inventory (STAI), which measures 2 anxiety dimensions, state and trait anxiety.
The numbers of CC, CT, and TT genotypes of rs182455 polymorphism were 227 (40.0%), 263 (46.4%), and 77 (13.6%), respectively. The genotype distribution did not deviate from the Hardy-Weinberg equilibrium ( = 0.004, = .953). There were no significant differences in either state or trait anxiety among the 3 rs182455 genotype groups ( = 0.457, 0.415, = .634, .660), between the 2 dominant model groups ( = 0.865, -0.195, = .388, .845), or between the 2 recessive model groups ( = 0.106, 0.906, = .916, .365). Moreover, no significant gender-specific differences in any STAI scores were found among the rs182455 genotype groups (all .05).
No evidence was demonstrated for the association of the gene polymorphism rs182455 with either trait or state anxiety in Chinese adults.
Stathmin 1（Stmn1）是一种与神经元生长相关的蛋白质，已发现其在动物和人类的恐惧处理过程中均发挥作用。此外，已有研究表明该基因的两个单核苷酸多态性（SNP）（rs182455和rs213641）在德国人中显著影响个体的恐惧和焦虑反应。然而，关于中国人群中这些SNP与焦虑之间的相关性尚无报道。因此，本研究旨在探讨这种相关性。
采用聚合酶链反应和限制性片段长度多态性分析，对567名健康汉族成年样本进行rs182455这一SNP的基因分型。焦虑状况通过中文版40项状态-特质焦虑量表（STAI）进行评估，该量表测量状态焦虑和特质焦虑两个维度。
rs182455多态性的CC、CT和TT基因型数量分别为227（40.0%）、263（46.4%）和77（13.6%）。基因型分布未偏离哈迪-温伯格平衡（χ² = 0.004，P = 0.953）。在3个rs182455基因型组之间（F = 0.457，0.415，P = 0.634，0.660）、两个显性模型组之间（F = 0.865， -0.195，P = 0.388，0.845）或两个隐性模型组之间（F = 0.106，0.906，P = 0.916，0.365），状态焦虑或特质焦虑均无显著差异。此外，在rs182455基因型组之间，未发现任何STAI评分存在显著的性别特异性差异（均P > 0.05）。
未发现该基因多态性rs182455与中国成年人的特质焦虑或状态焦虑之间存在关联。
