癌症干细胞与癌症起源细胞之间的复杂相互作用：对治疗策略的启示。
The intricate interplay between cancer stem cells and cell-of-origin of cancer: implications for therapeutic strategies.
作者信息
Bamodu Oluwaseun Adebayo, Chung Chen-Chih, Pisanic Thomas R, Wu Alexander T H
机构信息
Directorate of Postgraduate Studies, School of Clinical Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Ocean Road Cancer Institute, Dar es Salaam, Tanzania.
出版信息
Front Oncol. 2024 May 10;14:1404628. doi: 10.3389/fonc.2024.1404628. eCollection 2024.
BACKGROUND
Cancer stem cells (CSCs) have emerged as pivotal players in tumorigenesis, disease progression, and resistance to therapies.
OBJECTIVE
This comprehensive review delves into the intricate relationship between CSCs and the cell-of-origin in diverse cancer types.
DESIGN
Comprehensive review of thematically-relevant literature.
METHODS
We explore the underlying molecular mechanisms that drive the conversion of normal cells into CSCs and the impact of the cell-of-origin on CSC properties, tumor initiation, and therapeutic responses. Moreover, we discuss potential therapeutic interventions targeting CSCs based on their distinct cell-of-origin characteristics.
RESULTS
Accruing evidence suggest that the cell-of-origin, the cell type from which the tumor originates, plays a crucial role in determining the properties of CSCs and their contribution to tumor heterogeneity.
CONCLUSION
By providing critical insights into the complex interplay between CSCs and their cellular origins, this article aims to enhance our understanding of cancer biology and pave the way for more effective and personalized cancer treatments.
背景
癌症干细胞（CSCs）已成为肿瘤发生、疾病进展和治疗耐药性的关键因素。
目的
本综述深入探讨了不同癌症类型中癌症干细胞与起源细胞之间的复杂关系。
设计
对主题相关文献进行全面综述。
方法
我们探究了驱动正常细胞转化为癌症干细胞的潜在分子机制，以及起源细胞对癌症干细胞特性、肿瘤起始和治疗反应的影响。此外，我们还讨论了基于癌症干细胞独特的起源细胞特征的潜在治疗干预措施。
结果
越来越多的证据表明，起源细胞，即肿瘤起源的细胞类型，在决定癌症干细胞的特性及其对肿瘤异质性的贡献方面起着关键作用。
结论
通过深入了解癌症干细胞与其细胞起源之间的复杂相互作用，本文旨在增进我们对癌症生物学的理解，并为更有效和个性化的癌症治疗铺平道路。
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