Chandavarkar Vidyadevi, Mishra Mithilesh Narayan, Bhargava Deepak, Rajashekaraiah Premalatha Bidadi, Singh Shafali, Kanuru Vijay
Department of Oral and Maxillofacial Pathology and Oral Microbiology, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.
Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
J Oral Maxillofac Pathol. 2024 Jan-Mar;28(1):23-28. doi: 10.4103/jomfp.jomfp_420_23. Epub 2024 Apr 15.
Carbon monoxide (CO) concentrations in exhaled air may impart a quick, non-invasive method to determine smoking status. Haras is a nutraceutical medication, which is slowly gaining recognition for its antioxidant and anti-inflammatory activities.
The effectiveness of the Haras therapy in smokers and non-smokers will be assessed by evaluating breath CO levels.
The study included 101 test subjects with 76 subjects of smokers and 25 subjects of non-smokers. Both the test groups were given 10 mL of Haras juice in divided doses per day for 30 days. The CO levels were evaluated using a breath analyser before drug trial and then on the 8, 15, 22 and after the conclusion of the drug trial.
The Wilcoxon signed-rank test was used to compare the CO and carboxyhemoglobin levels among smokers and non-smokers.
Smokers had higher mean percent carboxyhemoglobin and mean parts per million CO values than non-smokers, and the difference between the two was shown to be statistically significant ( < 0.001). It was also found to be statistically significant from the first day to the eighth day, the first day to the 15 day, the first day to the 20 second day, first day to the 30 day ( < 0.001).
Haras can be used effectively as an alternative supportive treatment for the diminution of CO levels in smokers and non-smokers.
呼出气体中的一氧化碳（CO）浓度可能提供一种快速、非侵入性的方法来确定吸烟状态。哈拉斯是一种营养药物，其抗氧化和抗炎活性正逐渐得到认可。
通过评估呼出气体中的CO水平来评估哈拉斯疗法对吸烟者和非吸烟者的有效性。
该研究包括101名受试对象，其中76名吸烟者和25名非吸烟者。两个试验组每天分剂量服用10毫升哈拉斯果汁，持续30天。在药物试验前以及在第8天、第15天、第22天和药物试验结束后，使用呼吸分析仪评估CO水平。
采用Wilcoxon符号秩检验比较吸烟者和非吸烟者之间的CO和碳氧血红蛋白水平。
吸烟者的平均碳氧血红蛋白百分比和平均百万分率CO值高于非吸烟者，两者之间的差异具有统计学意义（<0.001）。从第一天到第八天、第一天到第十五天、第一天到第二十二天、第一天到第三十天也具有统计学意义（<0.001）。
哈拉斯可有效用作降低吸烟者和非吸烟者CO水平的替代支持性治疗方法。
