Naghsh Navid, Musazadeh Vali, Nikpayam Omid, Kavyani Zeynab, Moridpour Amir Hossein, Golandam Fatemeh, Faghfouri Amir Hossein, Ostadrahimi Alireza
Department of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Evid Based Complement Alternat Med. 2023 Jan 16;2023:4875636. doi: 10.1155/2023/4875636. eCollection 2023.
Several meta-analyses have shown that curcumin can reduce inflammatory biomarkers, but the findings are inconsistent. The objective of the present umbrella meta-analysis was to provide a more accurate estimate of the overall effects of curcumin on inflammatory biomarkers.
The following international databases were systematically searched until March 20, 2022: PubMed, Scopus, Embase, Web of Science, and Google Scholar. A random-effects model was applied to evaluate the effects of curcumin on inflammatory biomarkers. Meta-analysis studies investigating the effects of curcumin supplementation on inflammatory biomarkers with corresponding effect sizes (ES) and confidence intervals (CI) were included in the umbrella meta-analysis. GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to evaluate the certainty of evidence.
A meta-analyses of ten studies with 5,870 participants indicated a significant decrease in C-reactive protein (CRP) (ES = -0.74; 95% CI: -1.11, -0.37, < 0.001; I = 62.1%, =0.015), interleukin 6 (IL-6) (ES = -1.07; 95% CI: -1.71, -0.44, < 0.001; I = 75.6%, < 0.001), and tumour necrosis factor (TNF-) levels (ES: -1.92, 95% CI: -2.64, -1.19, < 0.0; I = 18.1%, =0.296) following curcumin supplementation. Greater effects on CRP and TNF- were evident in trials with a mean age >45 years and a sample size >300 participants.
The umbrella of meta-analysis suggests curcumin as a promising agent in reducing inflammation as an adjunctive therapeutic approach in diseases whose pathogenesis is related to a higher level of inflammatory biomarkers.
多项荟萃分析表明姜黄素可降低炎症生物标志物，但结果并不一致。本项汇总分析的目的是更准确地评估姜黄素对炎症生物标志物的总体影响。
系统检索了以下国际数据库直至2022年3月20日：PubMed、Scopus、Embase、Web of Science和谷歌学术。采用随机效应模型评估姜黄素对炎症生物标志物的影响。调查补充姜黄素对炎症生物标志物影响并具有相应效应大小（ES）和置信区间（CI）的荟萃分析研究纳入了汇总分析。使用GRADE（推荐分级评估、制定和评价）来评估证据的确定性。
一项纳入5870名参与者的十项研究的荟萃分析表明，补充姜黄素后C反应蛋白（CRP）（ES = -0.74；95%CI：-1.11，-0.37，P < 0.001；I² = 62.1%，P = 0.015）、白细胞介素6（IL-6）（ES = -1.07；95%CI：-1.71，-0.44，P < 0.001；I² = 75.6%，P < 0.001）和肿瘤坏死因子α（TNF-α）水平（ES：-1.92，95%CI：-2.64，-1.19，P < 0.001；I² = 18.1%，P = 0.296）显著降低。在平均年龄>45岁且样本量>300名参与者的试验中，对CRP和TNF-α的影响更大。
荟萃分析的汇总表明，姜黄素作为一种有前景的药物，在发病机制与较高水平炎症生物标志物相关的疾病中，作为辅助治疗方法可减轻炎症。
