Lynch T J, Siminoff R, Podolsky R, Adler M W
Department of Pharmacology, Temple University School of Medicine, Philadelphia, Pennsylvania.
J Ocul Pharmacol. 1985 Fall;1(3):255-61. doi: 10.1089/jop.1985.1.255.
Pupil area in rats was continuously monitored by infrared pupillometry during morphine-induced (30 mg/kg i.p.) mydriasis and pupillary fluctuations. EEG records from all visual system areas as well as frontal cortex, amygdala and mesencephalic reticular formation show intermittent electrographic bursting to be simultaneous with miosis during the period of fluctuations. Mydriasis occurs at the cessation of each burst, but both of these events occur 1-3 seconds after an effect on respiration composed of a slight change in tidal volume and a 10% decrease in minute respiratory rate. The reason for the essential synchrony of the respiratory change, the cessation of global bursting and the change in parasympathetic input to the pupil is unknown.
在吗啡诱导（腹腔注射30mg/kg）大鼠瞳孔散大及瞳孔波动过程中，通过红外瞳孔测量法持续监测大鼠的瞳孔面积。来自所有视觉系统区域以及额叶皮质、杏仁核和中脑网状结构的脑电图记录显示，在波动期间，间歇性的电图爆发与瞳孔缩小同时发生。每次爆发停止时会出现瞳孔散大，但这两个事件均在潮气量略有变化和分钟呼吸频率降低10%所构成的呼吸效应之后1 - 3秒发生。呼吸变化、整体爆发停止以及瞳孔副交感神经输入变化基本同步的原因尚不清楚。
