Department of Medical Genetics, Yeditepe University, Medical School, Istanbul, Turkey.
Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
Genes Chromosomes Cancer. 2024 May;63(5):e23248. doi: 10.1002/gcc.23248.
Meningiomas are non-glial tumors that are the most common primary brain tumors in adults. Although meningioma can possibly be cured with surgical excision, variations in atypical/anaplastic meningioma have a high recurrence rate and a poor prognosis. As a result, it is critical to develop novel therapeutic options for high-grade meningiomas. This review highlights the current histology of meningiomas, prevalent genetic and molecular changes, and the most extensively researched signaling pathways and therapies in meningiomas. It also reviews current clinical studies and novel meningioma treatments, including immunotherapy, microRNAs, cancer stem cell methods, and targeted interventions within the glycolysis pathway. Through the examination of the complex landscape of meningioma biology and the highlighting of promising therapeutic pathways, this review opens the way for future research efforts aimed at improving patient outcomes in this prevalent intracranial tumor entity.
脑膜瘤是非神经胶质肿瘤，是成人中最常见的原发性脑肿瘤。虽然脑膜瘤通过手术切除可能可以治愈，但非典型/间变性脑膜瘤的变化具有高复发率和预后不良。因此，开发高级别脑膜瘤的新治疗选择至关重要。本综述强调了脑膜瘤的当前组织学、常见的遗传和分子变化，以及在脑膜瘤中研究最多的信号通路和治疗方法。它还回顾了当前的临床研究和新型脑膜瘤治疗方法，包括免疫疗法、microRNAs、癌症干细胞方法以及糖酵解途径中的靶向干预。通过检查脑膜瘤生物学的复杂格局，并突出有前途的治疗途径，本综述为未来的研究工作开辟了道路，旨在改善这种常见的颅内肿瘤实体的患者预后。
