季节、户籍和孤立性出生缺陷：中国丹阳的一项基于人群的病例对照研究。
Season, household registry and isolated birth defects: a population-based case-control study in Danyang, China.
机构信息
D epar tment of Health Care, Women and Children Health Hospital of Zhenjiang, No. 20, Zhengdong Road, Zhenjiang 212003, China.
Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, No. 301, Xuefu Road, Zhenjiang 212013, China.
出版信息
Int Health. 2024 Sep 5;16(5):562-567. doi: 10.1093/inthealth/ihae034.
BACKGROUND
A birth population-based study was conducted in Danyang, Jiangsu Province, to evaluate major birth defects in emerging regions in China with similar maternal and neonatal care conditions.
METHODS
We conducted a population-based study in a cohort of infants born in Danyang from 2014 to 2021, including 55 709 perinatal infants. Four categories of isolated birth defects were defined as cases: congenital heart defects (CHDs; n=2138), polydactyly (n=145), cleft lip with or without palate (CL/P; n=76) and accessory auricles (n=93). Infants with congenital malformations were identified by the Chinese Birth Defects Monitoring Network.
RESULTS
Compared with autumn, conception in spring (OR=1.31 [1.16-1.48]) and winter (OR=1.39 [1.23-1.58]) was associated with an increased risk of CHD. Increased risk of CHD, CL/P and accessory auricles was significantly associated with non-local registered residence (OR=1.17 [1.07-1.28], OR=2.73 [1.52-4.88] and OR=2.11 [1.20-3.71], respectively). Individuals of Han nationality were less likely to have polydactyly (OR=0.23 [0.05-0.98]).
CONCLUSIONS
The season of pregnancy was significantly associated with CHDs. Offspring of mothers with non-local registered hometown had greater risks of CHDs, CL/P and accessory auricles.
背景
本研究在江苏省丹阳市开展了一项基于人群的研究，旨在评估具有相似母婴保健条件的中国新兴地区的主要出生缺陷情况。
方法
我们对 2014 年至 2021 年期间在丹阳市出生的 55709 例围产儿进行了一项基于人群的研究。将四类孤立性出生缺陷定义为病例：先天性心脏病（CHD；n=2138）、多指畸形（n=145）、唇裂伴或不伴腭裂（CL/P；n=76）和副耳（n=93）。先天性畸形患儿由中国出生缺陷监测网络确定。
结果
与秋季相比，春季（OR=1.31 [1.16-1.48]）和冬季（OR=1.39 [1.23-1.58]）受孕与 CHD 的风险增加相关。非本地户籍与 CHD、CL/P 和副耳的风险增加显著相关（OR=1.17 [1.07-1.28]、OR=2.73 [1.52-4.88]和 OR=2.11 [1.20-3.71]）。汉族个体发生多指畸形的风险较低（OR=0.23 [0.05-0.98]）。
结论
妊娠季节与 CHD 显著相关。母亲户籍地非本地的子女发生 CHD、CL/P 和副耳的风险较高。
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