Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Neurosci Bull. 2024 Nov;40(11):1681-1698. doi: 10.1007/s12264-024-01229-8. Epub 2024 May 27.
The orbitofrontal cortex (ORB), a region crucial for stimulus-reward association, decision-making, and flexible behaviors, extensively connects with other brain areas. However, brain-wide inputs to projection-defined ORB neurons and the distribution of inhibitory neurons postsynaptic to neurons in specific ORB subregions remain poorly characterized. Here we mapped the inputs of five types of projection-specific ORB neurons and ORB outputs to two types of inhibitory neurons. We found that different projection-defined ORB neurons received inputs from similar cortical and thalamic regions, albeit with quantitative variations, particularly in somatomotor areas and medial groups of the dorsal thalamus. By counting parvalbumin (PV) or somatostatin (SST) interneurons innervated by neurons in specific ORB subregions, we found a higher fraction of PV neurons in sensory cortices and a higher fraction of SST neurons in subcortical regions targeted by medial ORB neurons. These results provide insights into understanding and investigating the function of specific ORB neurons.
眶额皮层（ORB）是与刺激-奖励关联、决策和灵活行为至关重要的区域，与其他大脑区域广泛连接。然而，投射定义的 ORB 神经元的全脑输入以及特定 ORB 亚区神经元的抑制性神经元的突触后分布仍未得到很好的描述。在这里，我们绘制了五种类型的投射特异性 ORB 神经元和 ORB 输出到两种类型的抑制性神经元的输入。我们发现，不同投射定义的 ORB 神经元从相似的皮质和丘脑区域接收输入，尽管存在定量变化，特别是在躯体感觉区域和背侧丘脑的内侧群。通过计算特定 ORB 亚区神经元支配的神经元中的 parvalbumin（PV）或 somatostatin（SST）中间神经元的数量，我们发现来自感觉皮层的 PV 神经元比例较高，而来自内侧 ORB 神经元靶向的皮质下区域的 SST 神经元比例较高。这些结果为理解和研究特定 ORB 神经元的功能提供了线索。
