Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Department of Thoracic Oncology, The Second Affiliated Hospital of Zunyi Medical University, Guizhou, 56300, Zunyi, China.
Clin Exp Med. 2024 May 27;24(1):114. doi: 10.1007/s10238-024-01376-2.
Malignant tumors pose a grave threat to the quality of human life. The prevalence of malignant tumors in China is steadily rising. Presently, clinical interventions encompass surgery, radiotherapy, and pharmaceutical therapy in isolation or combination. Nonetheless, these modalities fail to completely eradicate malignant tumor cells, frequently leading to metastasis and recurrence. Conversely, tumor biotherapy has emerged as an encouraging fourth approach in preventing and managing malignant tumors owing to its safety, efficacy, and minimal adverse effects. Currently, a range of tumor biotherapy techniques are employed, including gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy. This study aims to comprehensively review the latest developments in biological treatments for malignant tumors.
恶性肿瘤严重威胁人类生命健康。目前，我国恶性肿瘤发病率呈持续上升态势，临床干预手段主要包括手术、放疗、药物治疗等单一或联合应用，但这些方法难以彻底清除肿瘤细胞，常导致肿瘤转移和复发。而肿瘤生物治疗以其安全性、有效性和低不良反应等优势，成为防治恶性肿瘤的第四种有效手段。目前，肿瘤生物治疗技术主要包括基因治疗、肿瘤疫苗、单克隆抗体治疗、肿瘤干细胞治疗、细胞因子治疗、过继性细胞免疫治疗等。本研究旨在对恶性肿瘤的生物治疗最新进展进行综述。
