SleepWell Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland.
SleepWell Research Program Unit, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland
eNeuro. 2024 Jun 4;11(6). doi: 10.1523/ENEURO.0453-23.2024. Print 2024 Jun.
Sleep's contribution to affective regulation is insufficiently understood. Previous human research has focused on memorizing or rating affective pictures and less on physiological affective responsivity. This may result in overlapping definitions of affective and declarative memories and inconsistent deductions for how rapid eye movement sleep (REMS) and slow-wave sleep (SWS) are involved. Literature associates REMS theta (4-8 Hz) activity with emotional memory processing, but its contribution to social stress habituation is unknown. Applying selective sleep stage suppression and oscillatory analyses, we investigated how sleep modulated affective adaptation toward social stress and retention of neutral declarative memories. Native Finnish participants ( = 29; age, = 25.8 years) were allocated to REMS or SWS suppression conditions. We measured physiological (skin conductance response, SCR) and subjective stress response and declarative memory retrieval thrice: before laboratory night, the next morning, and after 3 d. Linear mixed models were applied to test the effects of condition and sleep parameters on emotional responsivity and memory retrieval. Greater overnight increase in SCR toward the stressor emerged after suppressed SWS (intact REMS) relative to suppressed REMS (20.1% vs 6.1%; = 0.016). The overnight SCR increase was positively associated with accumulated REMS theta energy irrespective of the condition ( = 0.601; = 0.002). Subjectively rated affective response and declarative memory recall were comparable between the conditions. The contributions of REMS and SWS to habituation of social stress are distinct. REMS theta activity proposedly facilitates the consolidation of autonomic affective responses. Declarative memory consolidation may not have greater dependence on intact SWS relative to intact REMS.
睡眠对情感调节的贡献尚未得到充分理解。以前的人类研究集中在记忆或评估情感图片上，而对生理情感反应的研究较少。这可能导致情感和陈述性记忆的定义重叠，以及对快速眼动睡眠 (REMS) 和慢波睡眠 (SWS) 如何参与的推断不一致。文献将 REMS theta (4-8 Hz) 活动与情绪记忆处理相关联，但它对社会应激习惯形成的贡献尚不清楚。通过应用选择性睡眠阶段抑制和振荡分析，我们研究了睡眠如何调节对社会应激的情感适应以及对中性陈述性记忆的保留。将 29 名芬兰本地参与者（年龄 = 25.8 岁）分配到 REMS 或 SWS 抑制条件下。我们测量了生理（皮肤电反应，SCR）和主观应激反应以及陈述性记忆检索三次：在实验室之夜之前、第二天早上和 3 天后。线性混合模型用于测试条件和睡眠参数对情感反应性和记忆检索的影响。与抑制 REMS（20.1%）相比，抑制 SWS（完整 REMS）后，夜间对压力源的 SCR 增加更大（ = 0.016）。无论条件如何，夜间 SCR 增加与累积 REMS theta 能量呈正相关（ = 0.601； = 0.002）。条件之间的主观情感反应和陈述性记忆回忆相似。REMS 和 SWS 对社会应激习惯形成的贡献是不同的。REMS theta 活动可能有助于巩固自主情感反应。与完整的 REMS 相比，陈述性记忆巩固可能对完整的 SWS 没有更大的依赖性。
