Department of Neurology, Northwestern University, Chicago, IL, USA.
Department of Neuroscience, University of Sheffield, Sheffield, UK.
Commun Biol. 2021 Mar 25;4(1):404. doi: 10.1038/s42003-021-01854-3.
A growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.
越来越多的证据表明，睡眠有助于将情绪体验的记忆与其相关的情感负荷分离开来。这一过程被认为依赖于睡眠期间情绪记忆的自发重新激活，但对于哪种睡眠阶段最有利于这种重新激活仍不清楚。我们通过使用靶向记忆再激活（TMR）在快速眼动睡眠（REM）和慢波睡眠（SWS）中显式地操纵记忆再激活，并测试这种操纵对一夜之间主观唤醒反应习惯化的影响，来研究这个问题。我们的结果表明，REM 期间的 TMR 而非 SWS 显著降低了主观唤醒，而这种影响是由更负面的刺激驱动的。这些结果支持睡眠遗忘、睡眠记忆（SFSR）假说的一个方面，该假说提出 REM 睡眠期间的情绪记忆再激活是睡眠依赖性习惯化的基础。
