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探讨衰弱指数与中老年中国人腰痛之间的关联:来自中国健康与养老追踪调查(CHARLS)数据的横断面分析。

Exploring the association between Frailty Index and low back pain in middle-aged and older Chinese adults: a cross-sectional analysis of data from the China Health and Retirement Longitudinal Study (CHARLS).

机构信息

The First Clinical College, Beijing University of Chinese Medicine, Beijing, China.

Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing, China.

出版信息

BMJ Open. 2024 May 27;14(5):e085645. doi: 10.1136/bmjopen-2024-085645.

DOI:10.1136/bmjopen-2024-085645
PMID:38802272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11131124/
Abstract

OBJECTIVES

This study explored the association between the Frailty Index (FI) and low back pain (LBP) in middle-aged and older Chinese adults. We hypothesised that a higher FI correlates with increased LBP prevalence.

DESIGN

Cross-sectional analysis.

SETTING

The study used data from the China Health and Retirement Longitudinal Study (CHARLS) across various regions of China.

PARTICIPANTS

The analysis included 6375 participants aged 45 and above with complete LBP and FI data from the CHARLS for 2011, 2013 and 2015. We excluded individuals under 45, those with incomplete LBP data, participants with fewer than 30 health deficit items and those missing covariate data.

OUTCOME MEASURES

We constructed an FI consisting of 35 health deficits. Logistic multivariable regression examined the relationship between FI and LBP, using threshold analysis to identify inflection points. Sensitivity analyses were performed to ensure the robustness of the findings.

RESULTS

Of the participants, 27.2% reported LBP. A U-shaped association was observed between FI and LBP, with the highest quartile (Q4, FI ≥0.23) showing more than a twofold increased risk of LBP (OR=2.90, 95% CI: 2.45-3.42, p<0.001). Stratified analysis showed a significant association in participants under 60, particularly in the lowest FI quartile (OR=1.43, 95% CI: 1.14 to 1.79). Sensitivity analysis upheld the robustness of the primary results.

CONCLUSIONS

The findings suggest a complex relationship between frailty and LBP, highlighting the need for early screening and tailored interventions to manage LBP in this demographic. Further research is necessary to understand the mechanisms of this association and to validate the findings through longitudinal studies.

摘要

目的

本研究旨在探讨衰弱指数(FI)与中老年中国人腰痛(LBP)之间的关系。我们假设,FI 越高,LBP 的患病率就越高。

设计

横断面分析。

地点

本研究使用了来自中国健康与养老追踪调查(CHARLS)的数据,涵盖了中国不同地区。

参与者

分析纳入了来自 CHARLS 的 6375 名年龄在 45 岁及以上、在 2011、2013 和 2015 年有完整 LBP 和 FI 数据的参与者。我们排除了年龄小于 45 岁、LBP 数据不完整、健康缺陷项目少于 30 项以及存在协变量数据缺失的参与者。

结局指标

我们构建了一个由 35 个健康缺陷组成的 FI。采用逻辑多元回归分析 FI 与 LBP 之间的关系,并采用阈值分析确定拐点。进行了敏感性分析以确保研究结果的稳健性。

结果

参与者中,27.2%报告有腰痛。FI 与 LBP 之间呈 U 形关联,第四四分位(FI≥0.23)的 LBP 风险增加两倍以上(OR=2.90,95%CI:2.45-3.42,p<0.001)。分层分析显示,在 60 岁以下的参与者中存在显著关联,特别是在 FI 最低四分位(OR=1.43,95%CI:1.14-1.79)。敏感性分析支持主要结果的稳健性。

结论

研究结果表明衰弱与 LBP 之间存在复杂的关系,这凸显了在这一年龄段人群中早期筛查和量身定制干预措施来管理 LBP 的必要性。需要进一步研究以了解这种关联的机制,并通过纵向研究来验证这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11131124/8c56c12570a6/bmjopen-2024-085645f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11131124/8e12bb8e5374/bmjopen-2024-085645f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11131124/8c56c12570a6/bmjopen-2024-085645f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11131124/8e12bb8e5374/bmjopen-2024-085645f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e20/11131124/8c56c12570a6/bmjopen-2024-085645f02.jpg

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