Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
VASCage Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria.
Sci Rep. 2024 May 27;14(1):12063. doi: 10.1038/s41598-024-62557-3.
The systemic inflammatory response following acute ischaemic stroke remains incompletely understood. We characterised the circulating inflammatory profile in 173 acute ischaemic stroke patients by measuring 65 cytokines and chemokines in plasma. Participants were grouped based on their inflammatory response, determined by high-sensitivity C-reactive protein levels in the acute phase. We compared stroke patients' profiles with 42 people experiencing spontaneous cervical artery dissection without stroke. Furthermore, variations in cytokine levels among stroke aetiologies were analysed. Follow-up samples were collected in a subgroup of ischaemic stroke patients at three and twelve months. Ischaemic stroke patients had elevated plasma levels of HGF and SDF-1α, and lower IL-4 levels, compared to spontaneous cervical artery dissection patients without stroke. Aetiology-subgroup analysis revealed reduced levels of nine cytokines/chemokines (HGF, SDF-1α, IL-2R, CD30, TNF-RII, IL-16, MIF, APRIL, SCF), and elevated levels of IL-4 and MIP-1β, in spontaneous cervical artery dissection (with or without ischaemic stroke as levels were comparable between both groups) compared to other aetiologies. The majority of cytokine/chemokine levels remained stable across the study period. Our research indicates that stroke due to large artery atherosclerosis, cardioembolism, and small vessel occlusion triggers a stronger inflammatory response than spontaneous cervical artery dissection.
急性缺血性中风后全身炎症反应仍不完全清楚。我们通过测量血浆中的 65 种细胞因子和趋化因子，对 173 例急性缺血性中风患者的循环炎症谱进行了特征描述。参与者根据急性期高敏 C 反应蛋白水平的高低分为炎症反应组。我们将中风患者的情况与 42 例无中风的自发性颈内动脉夹层患者进行了比较。此外，还分析了中风病因中细胞因子水平的变化。在亚组缺血性中风患者中，在 3 个月和 12 个月时采集了随访样本。与无中风的自发性颈内动脉夹层患者相比，缺血性中风患者的血浆 HGF 和 SDF-1α水平升高，而 IL-4 水平降低。病因亚组分析显示，与其他病因相比，自发性颈内动脉夹层（伴有或不伴有缺血性中风，因为两组之间的水平相当）中 9 种细胞因子/趋化因子（HGF、SDF-1α、IL-2R、CD30、TNF-RII、IL-16、MIF、APRIL、SCF）的水平降低，而 IL-4 和 MIP-1β的水平升高。在研究期间，大多数细胞因子/趋化因子的水平保持稳定。我们的研究表明，大动脉粥样硬化、心源性栓塞和小血管闭塞引起的中风比自发性颈内动脉夹层引起的炎症反应更强。
