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The relation of synaptic biomarkers with Aβ, tau, glial activation, and neurodegeneration in Alzheimer's disease.

作者信息

Wang Yi-Ting, Ashton Nicholas J, Servaes Stijn, Nilsson Johanna, Woo Marcel S, Pascoal Tharick A, Tissot Cécile, Rahmouni Nesrine, Therriault Joseph, Lussier Firoza, Chamoun Mira, Gauthier Serge, Brinkmalm Ann, Zetterberg Henrik, Blennow Kaj, Rosa-Neto Pedro, Benedet Andréa L

机构信息

Translational Neuroimaging Laboratory, McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

出版信息

Transl Neurodegener. 2024 May 28;13(1):27. doi: 10.1186/s40035-024-00420-1.

DOI:10.1186/s40035-024-00420-1
PMID:38802928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11131272/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b963/11131272/1427c5b828c2/40035_2024_420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b963/11131272/1427c5b828c2/40035_2024_420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b963/11131272/1427c5b828c2/40035_2024_420_Fig1_HTML.jpg

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本文引用的文献

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Synaptic degeneration in Alzheimer disease.阿尔茨海默病中的突触退化
Nat Rev Neurol. 2023 Jan;19(1):19-38. doi: 10.1038/s41582-022-00749-z. Epub 2022 Dec 13.
2
Imaging of Synaptic Density in Neurodegenerative Disorders.神经退行性疾病中突触密度的影像学研究。
J Nucl Med. 2022 Jun;63(Suppl 1):60S-67S. doi: 10.2967/jnumed.121.263201.
3
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.通过靶向 mGluR5 防止 C1Q 对突触进行标记，逆转阿尔茨海默病小鼠模型中的突触丧失。
一种用于阿尔茨海默病和唐氏综合征中NPTX2的新型单分子阵列检测方法的开发与验证
Alzheimers Dement. 2025 Jun;21(6):e70241. doi: 10.1002/alz.70241.
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Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers.使用tau正电子发射断层扫描（PET）和血浆生物标志物预测阿尔茨海默病患者的纵向突触损失
Alzheimers Dement. 2025 May;21(5):e70333. doi: 10.1002/alz.70333.
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Biomarkers for synaptic dysfunction in Alzheimer's disease.阿尔茨海默病中突触功能障碍的生物标志物。
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