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Hartmann 手术后的发病率与直肠癌前切除术和腹会阴切除术的比较:一项基于人群的研究。

Postoperative morbidity following Hartmann's procedure in comparison to anterior resection and abdominoperineal resection for rectal cancer-a population-based study.

机构信息

Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden.

Lund University, Lund, Sweden.

出版信息

Colorectal Dis. 2024 Jun;26(6):1250-1257. doi: 10.1111/codi.17033. Epub 2024 May 27.

Abstract

AIM

There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry.

METHODS

All patients operated for rectal cancer, tumour height 5-15 cm, between the years 2010 and 2017, were identified through the Swedish colorectal cancer registry.

RESULTS

A total of 8476 patients were included: 1210 (14%) undergoing HP, 5406 (64%) AR and 1860 (22%) APR. HP was associated with an increased risk of intra-abdominal infection (OR 1.7, CI 1.26-2.28, P = 0.0004) compared to AR and APR, while APR was related to an increased risk of overall complications (OR 1.18, CI 1.01-1.40, P = 0.040). No significant difference was observed in the rate of reoperations and readmissions between HP, AR and APR, and type of surgical procedure was not a risk factor for 30-day mortality. Findings from a subgroup analysis of patients with a tumour 5-7 cm from the anal verge revealed that HP was not associated with increased risk for complications or 30-day mortality.

CONCLUSIONS

For patients where AR is not appropriate HP is a valid alternative with a favourable outcome. APR was associated with the highest overall 30-day complication rate.

摘要

目的

关于直肠癌症治疗中应在多大程度上采用 Hartmann 手术(HP)一直存在争议。本研究旨在通过国家登记处调查 HP、前切除术(AR)和腹会阴切除术(APR)治疗直肠癌症的 30 天术后发病率和死亡率。

方法

通过瑞典结直肠癌登记处,确定了 2010 年至 2017 年间接受直肠癌症手术、肿瘤高度为 5-15cm 的所有患者。

结果

共纳入 8476 例患者:1210 例(14%)行 HP,5406 例(64%)行 AR,1860 例(22%)行 APR。与 AR 和 APR 相比,HP 与腹腔内感染的风险增加相关(OR 1.7,95%CI 1.26-2.28,P=0.0004),而 APR 与总体并发症的风险增加相关(OR 1.18,95%CI 1.01-1.40,P=0.040)。HP、AR 和 APR 之间在再次手术和再入院率方面没有差异,手术类型也不是 30 天死亡率的危险因素。肛门缘 5-7cm 肿瘤患者亚组分析的结果表明,HP 并不增加并发症或 30 天死亡率的风险。

结论

对于不适合 AR 的患者,HP 是一种可行的替代方案,结果良好。APR 与总体 30 天并发症发生率最高。

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