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Hartmann 手术后的发病率与直肠癌前切除术和腹会阴切除术的比较:一项基于人群的研究。

Postoperative morbidity following Hartmann's procedure in comparison to anterior resection and abdominoperineal resection for rectal cancer-a population-based study.

机构信息

Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden.

Lund University, Lund, Sweden.

出版信息

Colorectal Dis. 2024 Jun;26(6):1250-1257. doi: 10.1111/codi.17033. Epub 2024 May 27.

DOI:10.1111/codi.17033
PMID:38802985
Abstract

AIM

There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry.

METHODS

All patients operated for rectal cancer, tumour height 5-15 cm, between the years 2010 and 2017, were identified through the Swedish colorectal cancer registry.

RESULTS

A total of 8476 patients were included: 1210 (14%) undergoing HP, 5406 (64%) AR and 1860 (22%) APR. HP was associated with an increased risk of intra-abdominal infection (OR 1.7, CI 1.26-2.28, P = 0.0004) compared to AR and APR, while APR was related to an increased risk of overall complications (OR 1.18, CI 1.01-1.40, P = 0.040). No significant difference was observed in the rate of reoperations and readmissions between HP, AR and APR, and type of surgical procedure was not a risk factor for 30-day mortality. Findings from a subgroup analysis of patients with a tumour 5-7 cm from the anal verge revealed that HP was not associated with increased risk for complications or 30-day mortality.

CONCLUSIONS

For patients where AR is not appropriate HP is a valid alternative with a favourable outcome. APR was associated with the highest overall 30-day complication rate.

摘要

目的

关于直肠癌症治疗中应在多大程度上采用 Hartmann 手术(HP)一直存在争议。本研究旨在通过国家登记处调查 HP、前切除术(AR)和腹会阴切除术(APR)治疗直肠癌症的 30 天术后发病率和死亡率。

方法

通过瑞典结直肠癌登记处,确定了 2010 年至 2017 年间接受直肠癌症手术、肿瘤高度为 5-15cm 的所有患者。

结果

共纳入 8476 例患者:1210 例(14%)行 HP,5406 例(64%)行 AR,1860 例(22%)行 APR。与 AR 和 APR 相比,HP 与腹腔内感染的风险增加相关(OR 1.7,95%CI 1.26-2.28,P=0.0004),而 APR 与总体并发症的风险增加相关(OR 1.18,95%CI 1.01-1.40,P=0.040)。HP、AR 和 APR 之间在再次手术和再入院率方面没有差异,手术类型也不是 30 天死亡率的危险因素。肛门缘 5-7cm 肿瘤患者亚组分析的结果表明,HP 并不增加并发症或 30 天死亡率的风险。

结论

对于不适合 AR 的患者,HP 是一种可行的替代方案,结果良好。APR 与总体 30 天并发症发生率最高。

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