• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

丙烯基异硫氰酸酯对口腔细菌感染后生存和抗菌肽表达的影响。

Effect of allyl-isothiocyanate on survival and antimicrobial peptide expression following oral bacterial infections in .

机构信息

Institute of Nutritional Science, Justus Liebig University, Giessen, Germany.

Centre for Sustainable Food Systems, Justus Liebig University, Giessen, Germany.

出版信息

Front Immunol. 2024 May 13;15:1404086. doi: 10.3389/fimmu.2024.1404086. eCollection 2024.

DOI:10.3389/fimmu.2024.1404086
PMID:38803500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11128604/
Abstract

Since infections with antibiotic-resistant bacteria cause increasing problems worldwide, the identification of alternative therapies is of great importance. Plant-derived bioactives, including allyl-isothiocyanate (AITC), have received attention for their antimicrobial properties. The present study therefore investigates the impact of AITC on survival and antimicrobial peptide (AMP) levels in challenged with the fly pathogenic bacteria subsp. and . AITC, a sulfur-containing compound derived from glucosinolates, exhibits antimicrobial properties and has been suggested to modulate AMP expression. By using , we demonstrate that AITC treatment resulted in a concentration-dependent decrease of survival rates among female flies, particularly in the presence of the Gram-negative bacterium subsp. , whereas AITC did not affect survival in male flies. Despite the ability of isothiocyanates to induce AMP expression in cell culture, we did not detect significant changes in AMP mRNA levels in infected flies exposed to AITC. Our findings suggest sex-specific differences in response to AITC treatment and bacterial infections, underlining the complexity of host-pathogen interactions and potential limitations of AITC as a preventive or therapeutic compound at least in models of bacterial infections.

摘要

由于抗生素耐药菌感染在全球范围内造成的问题日益严重，因此寻找替代疗法非常重要。植物来源的生物活性物质，包括丙烯基异硫氰酸酯（AITC），因其具有抗菌特性而受到关注。因此，本研究调查了 AITC 对感染 fly 病原菌 亚种 和 的存活和抗菌肽（AMP）水平的影响。AITC 是一种源自硫代葡萄糖苷的含硫化合物，具有抗菌特性，并被认为可以调节 AMP 表达。通过使用 ，我们证明 AITC 处理导致雌性果蝇的存活率呈浓度依赖性下降，特别是在革兰氏阴性菌 亚种 存在的情况下，而 AITC 处理对雄性果蝇的存活率没有影响。尽管异硫氰酸盐能够在细胞培养中诱导 AMP 表达，但我们没有检测到暴露于 AITC 的感染果蝇中 AMP mRNA 水平的显著变化。我们的研究结果表明，对 AITC 处理和细菌感染的反应存在性别特异性差异，这突显了宿主-病原体相互作用的复杂性，以及 AITC 作为预防或治疗化合物的潜在局限性，至少在细菌感染的 模型中是如此。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/965923022fb0/fimmu-15-1404086-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/670264791753/fimmu-15-1404086-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/2c648e2483cf/fimmu-15-1404086-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/389ce070936a/fimmu-15-1404086-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/9b8d2b192a70/fimmu-15-1404086-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/679fb1c8eac3/fimmu-15-1404086-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/2d8c9168647d/fimmu-15-1404086-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/4a8e31e78845/fimmu-15-1404086-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/e9992d6a92d0/fimmu-15-1404086-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/c38726c1cb41/fimmu-15-1404086-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/9f9e4fbd5c15/fimmu-15-1404086-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/965923022fb0/fimmu-15-1404086-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/670264791753/fimmu-15-1404086-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/2c648e2483cf/fimmu-15-1404086-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/389ce070936a/fimmu-15-1404086-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/9b8d2b192a70/fimmu-15-1404086-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/679fb1c8eac3/fimmu-15-1404086-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/2d8c9168647d/fimmu-15-1404086-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/4a8e31e78845/fimmu-15-1404086-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/e9992d6a92d0/fimmu-15-1404086-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/c38726c1cb41/fimmu-15-1404086-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/9f9e4fbd5c15/fimmu-15-1404086-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de58/11128604/965923022fb0/fimmu-15-1404086-g011.jpg

相似文献

1
Effect of allyl-isothiocyanate on survival and antimicrobial peptide expression following oral bacterial infections in .丙烯基异硫氰酸酯对口腔细菌感染后生存和抗菌肽表达的影响。
Front Immunol. 2024 May 13;15:1404086. doi: 10.3389/fimmu.2024.1404086. eCollection 2024.
2
Behavioral Aversion to AITC Requires Both and in .对AITC 的行为回避需要 和 两者都存在于 中。
Front Neural Circuits. 2018 Jul 3;12:45. doi: 10.3389/fncir.2018.00045. eCollection 2018.
3
Allyl isothiocyanate as a cancer chemopreventive phytochemical.丙烯基异硫氰酸酯作为一种癌症化学预防植物化学物质。
Mol Nutr Food Res. 2010 Jan;54(1):127-35. doi: 10.1002/mnfr.200900323.
4
Inhibition of Campylobacter jejuni on fresh chicken breasts by κ-carrageenan/chitosan-based coatings containing allyl isothiocyanate or deodorized oriental mustard extract.含异硫氰酸烯丙酯或除臭芥菜提取物的κ-卡拉胶/壳聚糖基涂层对新鲜鸡胸肉上空肠弯曲菌的抑制作用
Int J Food Microbiol. 2014 Sep 18;187:77-82. doi: 10.1016/j.ijfoodmicro.2014.07.003. Epub 2014 Jul 11.
5
Erwinia carotovora Quorum Sensing System Regulates Host-Specific Virulence Factors and Development Delay in Drosophila melanogaster.胡萝卜软腐欧文氏菌群体感应系统调控果蝇中宿主特异性毒力因子和发育迟缓。
mBio. 2020 Jun 23;11(3):e01292-20. doi: 10.1128/mBio.01292-20.
6
Control of Salmonella enterica and Listeria monocytogenes in hummus using allyl isothiocyanate.利用丙烯基异硫氰酸酯控制肠沙门氏菌和单核细胞增生李斯特菌在鹰嘴豆泥中的生长。
Int J Food Microbiol. 2018 Aug 2;278:73-80. doi: 10.1016/j.ijfoodmicro.2018.04.033. Epub 2018 Apr 21.
7
Pleiotropic effects of N-acylhomoserine lactone synthase ExpI on virulence, competition, and transmission in Pectobacterium carotovorum subsp. carotovorum Pcc21.N-酰基高丝氨酸内酯合酶 ExpI 对胡萝卜软腐果胶杆菌亚种胡萝卜软腐亚种 Pcc21 毒力、竞争和传播的多效性作用。
Pest Manag Sci. 2024 Feb;80(2):687-697. doi: 10.1002/ps.7797. Epub 2023 Oct 11.
8
Development of a Bacteriophage Cocktail against Pectobacterium carotovorum Subsp. and Its Effects on Virulence.开发一种针对果胶杆菌亚种的噬菌体鸡尾酒及其对毒力的影响。
Appl Environ Microbiol. 2022 Oct 11;88(19):e0076122. doi: 10.1128/aem.00761-22. Epub 2022 Sep 27.
9
Multidirectional time-dependent effect of sinigrin and allyl isothiocyanate on metabolic parameters in rats.黑芥子硫苷酸钾和丙烯基异硫氰酸酯对大鼠代谢参数的多向时变作用。
Plant Foods Hum Nutr. 2010 Sep;65(3):217-24. doi: 10.1007/s11130-010-0183-3.
10
Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in males and females.果蝇中谷胱甘肽转移酶E7的过表达对雄性和雌性果蝇体内有机异硫氰酸盐的毒性有不同影响。
PLoS One. 2014 Oct 16;9(10):e110103. doi: 10.1371/journal.pone.0110103. eCollection 2014.

引用本文的文献

1
Curcumin Induces Transgenerational and Sex-Specific Effects on Lifespan, Gene Expression, and Metabolism in the Fruit Fly Drosophila melanogaster.姜黄素对黑腹果蝇的寿命、基因表达和代谢产生跨代及性别特异性影响。
Biofactors. 2025 Jul-Aug;51(4):e70039. doi: 10.1002/biof.70039.
2
Drosophila melanogaster as a model organism to investigate sex specific differences.黑腹果蝇作为一种用于研究性别特异性差异的模式生物。
Sci Rep. 2025 Jun 4;15(1):19648. doi: 10.1038/s41598-025-04497-0.
3
Odorant receptors tuned to isothiocyanates in are co-opted and expanded in herbivorous relatives.

本文引用的文献

1
Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways.丙烯基异硫氰酸酯通过与多种细胞信号通路相互作用，调节氧化应激、炎症、细胞增殖、细胞周期停滞、细胞凋亡、血管生成、侵袭和转移。
Histochem Cell Biol. 2024 Mar;161(3):211-221. doi: 10.1007/s00418-023-02255-9. Epub 2023 Nov 29.
2
An update on the potential mechanism of gallic acid as an antibacterial and anticancer agent.没食子酸作为抗菌和抗癌剂的潜在机制的最新进展。
Food Sci Nutr. 2023 Aug 31;11(10):5856-5872. doi: 10.1002/fsn3.3615. eCollection 2023 Oct.
3
在[具体对象]中，对异硫氰酸酯有反应的气味受体在食草动物亲属中被征用并扩展。
bioRxiv. 2025 Mar 10:2024.10.08.617316. doi: 10.1101/2024.10.08.617316.
Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use.
抗菌肽：走向医药、生物医学和化妆品应用的挑战之旅。
Int J Mol Sci. 2023 May 20;24(10):9031. doi: 10.3390/ijms24109031.
4
Antimicrobial peptides for combating drug-resistant bacterial infections.用于对抗耐药细菌感染的抗菌肽。
Drug Resist Updat. 2023 May;68:100954. doi: 10.1016/j.drup.2023.100954. Epub 2023 Mar 1.
5
Antimicrobial Compounds in Food Packaging.食品包装中的抗菌化合物。
Int J Mol Sci. 2023 Jan 27;24(3):2457. doi: 10.3390/ijms24032457.
6
Anthocyanins in Plant Food: Current Status, Genetic Modification, and Future Perspectives.植物性食物中的花色苷：现状、遗传修饰及未来展望。
Molecules. 2023 Jan 15;28(2):866. doi: 10.3390/molecules28020866.
7
Anticancer Activity, Mechanism, and Delivery of Allyl Isothiocyanate.异硫氰酸烯丙酯的抗癌活性、作用机制及递送
Bioengineering (Basel). 2022 Sep 14;9(9):470. doi: 10.3390/bioengineering9090470.
8
Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues.先天免疫涉及多个信号通路以及不同组织之间的协调通信。
Front Immunol. 2022 Jul 7;13:905370. doi: 10.3389/fimmu.2022.905370. eCollection 2022.
9
A single mating is sufficient to induce persistent reduction of immune defense in mated female Drosophila melanogaster.一次交配足以诱导交配后的雌性黑腹果蝇免疫防御的持续降低。
J Insect Physiol. 2022 Jul;140:104414. doi: 10.1016/j.jinsphys.2022.104414. Epub 2022 Jun 18.
10
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.2019 年全球细菌对抗菌药物耐药性的负担：系统分析。
Lancet. 2022 Feb 12;399(10325):629-655. doi: 10.1016/S0140-6736(21)02724-0. Epub 2022 Jan 19.