Ophir Loyola Hospital, Belém 66063-240, Brazil.
Oncology Research Center, Federal University of Pará, Belém 66073-000, Brazil.
Med Sci (Basel). 2024 May 6;12(2):24. doi: 10.3390/medsci12020024.
Gastric cancer has been demonstrating a reduction in the number of cases over the past decades, largely attributed to advancements in public health practices and increased accessibility to educational initiatives for the general population. Nevertheless, it persists as the third leading cause of mortality globally among both men and women. These fatalities are typically associated with delayed disease detection. The current study assessed the levels of homocysteine, vitamin B12, and folic acid as a means of establishing a screening biomarker profile that could be integrated into routine testing protocols to facilitate swift diagnosis of the illness. A total of 207 control subjects and 207 individuals with gastric cancer were scrutinized, with biochemical measurements conducted using chemiluminescence for homocysteine, folic acid, and vitamin B12. The two groups were matched based on age, tumor location, subtype, tumor classification, presence of Epstein-Barr Virus infection (EBV), and Helicobacter pylori (). Significant statistical variances were identified in the mean levels of the triad of substances among cancer patients when compared to the control group for all corresponding variables. In conclusion, our study indicated that analyzing the triad of homocysteine, vitamin B12, and folic acid holds diagnostic value for gastric cancer and could potentially serve as an effective screening marker for this type of cancer in the future.
在过去几十年中，胃癌的病例数量一直在减少，这主要归因于公共卫生实践的进步和大众获得教育机会的增加。然而，胃癌仍然是男性和女性全球死亡率第三高的疾病。这些死亡通常与疾病的延迟发现有关。本研究评估了同型半胱氨酸、维生素 B12 和叶酸的水平，以期建立一种筛查生物标志物谱，可以将其纳入常规检测方案，以促进对该疾病的快速诊断。共检查了 207 名对照受试者和 207 名胃癌患者，使用化学发光法测量同型半胱氨酸、叶酸和维生素 B12 的生化指标。两组在年龄、肿瘤位置、亚型、肿瘤分类、是否存在 Epstein-Barr 病毒感染（EBV）和幽门螺杆菌（）方面进行了匹配。与对照组相比，癌症患者组的同型半胱氨酸、维生素 B12 和叶酸三联体的平均水平存在显著的统计学差异。总之，我们的研究表明，分析同型半胱氨酸、维生素 B12 和叶酸三联体对胃癌具有诊断价值，并且将来可能成为这种癌症的有效筛查标志物。
