Institute of Drug Discovery Technology, Ningbo University, 315211 Zhejiang, China.
School of Materials and Chemical Engineering, Ningbo University of Technology, 315211 Ningbo, Zhejiang, China.
Org Lett. 2024 Jun 7;26(22):4700-4704. doi: 10.1021/acs.orglett.4c01471. Epub 2024 May 28.
CpFe-mediated electrochemical synthesis of phosphorylated indoles and Trp-containing oligopeptides has been developed, which eliminates the need for external oxidants and yields the desired products in moderate to excellent yields under mild conditions. Importantly, the synthetic applicability was further demonstrated through its easy scalability and the anticancer activity of the product. Remarkably, it presents the first electrochemical protocol to access the phosphorylation of indoles and Trp-containing oligopeptides.
已开发出 CpFe 介导的磷酸化吲哚和色氨酸残基寡肽的电化学合成方法，该方法无需使用外部氧化剂，并且在温和条件下以中等至优异的产率得到所需产物。重要的是，通过其易于扩大规模以及产物的抗癌活性进一步证明了该合成方法的适用性。值得注意的是，它提出了第一个电化学方法来实现吲哚和色氨酸残基寡肽的磷酸化。
