Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10125 Torino Italy.
Sci Signal. 2024 May 28;17(838):eadp3504. doi: 10.1126/scisignal.adp3504.
The Hippo pathway blocks epithelial-mesenchymal transition and metastasis in cancer mediated by the transcriptional coactivator YAP. In this issue of , Palamiuc demonstrate that phosphatidylinositol 5-phosphate (PI5P) enhances Hippo pathway activation and that simultaneously the Hippo pathway initiates a positive feedback loop by inhibiting the conversion of PI5P into PIP.
Hippo 通路通过转录共激活因子 YAP 阻断癌症中的上皮-间充质转化和转移。在本期 中，Palamiuc 证明了磷脂酰肌醇 5-磷酸 (PI5P) 增强了 Hippo 通路的激活，同时 Hippo 通路通过抑制 PI5P 转化为 PIP 来启动正反馈环。
