Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Database (Oxford). 2024 May 28;2024. doi: 10.1093/database/baae040.
Mechanical aspects of tissues and cells critically influence a myriad of biological processes and can substantially alter the course of diverse diseases. The emergence of diverse methodologies adapted from physical science now permits the precise quantification of the cellular forces and the mechanical properties of tissues and cells. Despite the rising interest in tissue and cellular mechanics across fields like biology, bioengineering and medicine, there remains a noticeable absence of a comprehensive and readily accessible repository of this pertinent information. To fill this gap, we present MechanoBase, a comprehensive tissue and cellular mechanics database, curating 57 480 records from 5634 PubMed articles. The records archived in MechanoBase encompass a range of mechanical properties and forces, such as modulus and tractions, which have been measured utilizing various technical approaches. These measurements span hundreds of biosamples across more than 400 species studied under diverse conditions. Aiming for broad applicability, we design MechanoBase with user-friendly search, browsing and data download features, making it a versatile tool for exploring biomechanical attributes in various biological contexts. Moreover, we add complementary resources, including the principles of popular techniques, the concepts of mechanobiology terms and the cellular and tissue-level expression of related genes, offering scientists unprecedented access to a wealth of knowledge in this field of research. Database URL: https://zhanglab-web.tongji.edu.cn/mechanobase/ and https://compbio-zhanglab.org/mechanobase/.
组织和细胞的力学特性对多种生物学过程起着至关重要的影响作用，并且可以显著改变多种疾病的进程。现在，各种物理科学方法的出现使得对细胞力和组织及细胞的机械特性进行精确量化成为可能。尽管生物学、生物工程和医学等领域对组织和细胞力学的兴趣日益浓厚，但仍然明显缺乏一个全面且易于获取的相关信息库。为了填补这一空白，我们创建了 MechanoBase，这是一个全面的组织和细胞力学数据库，从 5634 篇 PubMed 文章中整理了 57480 条记录。MechanoBase 中归档的记录涵盖了广泛的力学特性和力，例如模量和牵引力，这些特性和力是利用各种技术方法测量得到的。这些测量结果跨越了数百个生物样本，涉及 400 多种不同物种在各种条件下的研究。为了实现广泛的适用性，我们设计了 MechanoBase，其具有用户友好的搜索、浏览和数据下载功能，使其成为探索各种生物学背景下生物力学属性的多功能工具。此外，我们还添加了补充资源，包括流行技术的原理、机械生物学术语的概念以及相关基因在细胞和组织水平上的表达，为科学家提供了在这一研究领域获取丰富知识的前所未有的途径。数据库网址：https://zhanglab-web.tongji.edu.cn/mechanobase/ 和 https://compbio-zhanglab.org/mechanobase/。
