纤维弹性成像技术 - TE-CAP 无创诊断儿童肝脂肪变的临床研究。
Clinical research of fibroscan ‒ TE-CAP at noninvasive diagnosis of hepatic steatosis in children.
机构信息
Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing City, China.
Department of Gastroenterology, Shenzhen Children's Hospital, Shenzhen City, China.
出版信息
Clinics (Sao Paulo). 2024 May 27;79:100387. doi: 10.1016/j.clinsp.2024.100387. eCollection 2024.
BACKGROUND & AIMS: The authors assess the diagnostic accuracy of the Transient Elastography-Controlled Attenuation Parameter (TE-CAP) in children of Southern China.
METHODS
105 obese or overweight children and adolescents were enrolled in the diagnostic test of TE-CAP assessment of hepatic steatosis using MRI-PDFF. Hepatic steatosis grades S0-S3 were classified. Statistical correlation, agreement and consistency between methods were evaluated. The diagnostic efficiency of TE-CAP was evaluated. The authors used the cutoff value of TE-CAP to detect hepatic steatosis in another 356 children.
RESULTS
The Area Under Curve (AUC) of TE-CAP for grade ≥ S1, ≥ S2, and ≥ S3 steatosis were 0.975, 0.984, and 0.997, respectively. For detecting ≥ S1 steatosis, TE-CAP had a sensitivity of 96 % and a specificity of 97 %. For detecting ≥ S2 steatosis, TE-CAP had a sensitivity of 97 % and a specificity of 93 %. For detecting ≥ S3 steatosis, TE-CAP had a sensitivity of 1 and a specificity of 94 %. TE-CAP and MRI-PDFF had a linear correlation (r = 0. 0.87, p < 0.001). The hepatic steatosis was identified in 40.2 % (143/356) of children in which the obesity and overweight were 69.8 % (113/162) and 40.0 % (18/45).
CONCLUSION
TE-CAP showed excellent diagnostic accuracy in pediatric hepatic steatosis.
背景与目的
本研究旨在评估南方儿童瞬态弹性成像控制衰减参数（TE-CAP）在诊断肝脂肪变性中的准确性。
方法
共纳入 105 例肥胖或超重的儿童和青少年，采用 MRI-PDFF 对 TE-CAP 评估肝脂肪变性进行诊断检测。将肝脂肪变性分为 S0-S3 级。评估各方法间的统计学相关性、一致性和符合率。评估 TE-CAP 的诊断效率。作者使用 TE-CAP 的临界值在另外 356 例儿童中检测肝脂肪变性。
结果
TE-CAP 对≥S1、≥S2 和≥S3 级肝脂肪变性的曲线下面积（AUC）分别为 0.975、0.984 和 0.997。对于检测≥S1 级肝脂肪变性，TE-CAP 的敏感性为 96%，特异性为 97%。对于检测≥S2 级肝脂肪变性，TE-CAP 的敏感性为 97%，特异性为 93%。对于检测≥S3 级肝脂肪变性，TE-CAP 的敏感性为 1，特异性为 94%。TE-CAP 与 MRI-PDFF 具有线性相关性（r=0.87，p<0.001）。在肥胖和超重的 162 例（69.8%）和 45 例（40.0%）儿童中，有 40.2%（143/356）的儿童存在肝脂肪变性。
结论
TE-CAP 在儿童肝脂肪变性中具有优异的诊断准确性。
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