Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang, 212013, People's Republic of China.
Department of Mechanical Engineering, International University of Business Agriculture and Technology, Dhaka, 1230, Bangladesh.
Biomed Phys Eng Express. 2024 Jun 5;10(4). doi: 10.1088/2057-1976/ad50da.
Atherosclerosis is a cardiovascular disease mainly caused by plaque deposition in blood vessels. Plaque comprises components such as thrombosis, fibrin, collagen, and lipid core. It plays an essential role in inducing rupture in a blood vessel. Generally, Plaque could be described as three kinds of elastic models: cellular Plaque, hypocellular Plaque, and calcified Plaque. The present study aimed to investigate the behavior of atherosclerotic plaque rupture according to different lipid cores using Fluid-Structure Interaction (FSI). The blood vessel was also varied with different thicknesses (0.05, 0.25, and 0.5 mm). In this study, FSI simulation with a cellular plaque model with various thicknesses was investigated to obtain information on plaque rupture. Results revealed that the blood vessel with Plaque having a lipid core represents higher stresses than those without a lipid core. Blood vessels' thin thickness, like a thin cap, results in more considerable than Von Mises stress. The result also suggests that even at low fracture stress, the risk of rupture due to platelet decomposition at the gap was more significant for cellular plaques.
动脉粥样硬化是一种心血管疾病，主要由血管内斑块沉积引起。斑块由血栓、纤维蛋白、胶原和脂质核心等成分组成。它在诱导血管破裂中起着至关重要的作用。通常，斑块可以描述为三种弹性模型：细胞性斑块、少细胞性斑块和钙化斑块。本研究旨在使用流固耦合（FSI）研究不同脂质核心的动脉粥样硬化斑块破裂行为。血管的厚度也有所不同（0.05、0.25 和 0.5 毫米）。在这项研究中，研究了具有不同厚度的细胞斑块模型的 FSI 模拟，以获取有关斑块破裂的信息。结果表明，含有脂质核心的斑块的血管比没有脂质核心的血管具有更高的应力。血管的薄厚度，如薄帽，会导致更大的 Von Mises 应力。结果还表明，即使在低断裂应力下，由于血小板在间隙处分解而导致破裂的风险对于细胞斑块来说也更为显著。
