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长期接受全身剂量治疗的患者结膜中四环素的分布情况。

Distribution of tetracycline in the conjunctiva of patients on long term systemic doses.

作者信息

Dilly P N, Mackie I A

出版信息

Br J Ophthalmol. 1985 Jan;69(1):25-8. doi: 10.1136/bjo.69.1.25.

DOI:10.1136/bjo.69.1.25
PMID:3880640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1040516/
Abstract

After oral administration of tetracycline fluorescence has been detected in biopsy specimens taken from human and animal conjunctiva. The fluorescence is not uniform but appears to be concentrated in the goblet cells, around the blood vessels, and in a thin film on the external surface of the epithelium. Immersion studies suggest there is a selective binding to the surface of the conjunctiva.

摘要

口服四环素后,在取自人和动物结膜的活检标本中检测到了荧光。荧光并不均匀,似乎集中在杯状细胞、血管周围以及上皮外表面的一层薄膜中。浸泡研究表明,结膜表面存在选择性结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbcc/1040516/677778d417e6/brjopthal00133-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbcc/1040516/677778d417e6/brjopthal00133-0028-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbcc/1040516/677778d417e6/brjopthal00133-0028-a.jpg

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本文引用的文献

1
In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracycline.
J Am Acad Dermatol. 1983 Jun;8(6):807-12. doi: 10.1016/s0190-9622(83)80010-3.
2
The distribution in the skin of systemically administered tetracycline.全身给药的四环素在皮肤中的分布。
Br J Dermatol. 1969 Jun;81(6):448-51. doi: 10.1111/j.1365-2133.1969.tb14016.x.
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Tetracyclines in the treatment of ocular rosacea.四环素在眼部酒渣鼻治疗中的应用
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4
Tetracycline levels in skin surface film after oral administration of tetracycline to normal adults and to patients with acne vulgaris.正常成年人及寻常痤疮患者口服四环素后皮肤表面膜中的四环素水平。
J Invest Dermatol. 1967 Dec;49(6):611-5. doi: 10.1038/jid.1967.188.
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A clinical trial of tetracycline in rosacea.
Br J Dermatol. 1966 Dec;78(12):649-52. doi: 10.1111/j.1365-2133.1966.tb12168.x.
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Tetracycline for the treatment of pityriasis lichenoides.
Br J Dermatol. 1974 Sep;91(3):319-22. doi: 10.1111/j.1365-2133.1974.tb12902.x.
7
Panniculitis (Rothmann-Makai), with good response to tetracycline.
Br J Dermatol. 1975 Mar;92(3):351-4. doi: 10.1111/j.1365-2133.1975.tb03088.x.
8
Diagnosis and treatment of ocular rosacea.眼部酒渣鼻的诊断与治疗。
Ophthalmology. 1978 Aug;85(8):779-86. doi: 10.1016/s0161-6420(78)35619-0.
9
The treatment of steroid-induced rosacea and perioral dermatitis.类固醇诱导的酒渣鼻和口周皮炎的治疗。
Dermatologica. 1976;152 Suppl 1:231-7. doi: 10.1159/000257894.