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创新的社区同伴主导干预对 15-24 岁青少年和年轻人获得和使用性与生殖健康服务的影响:来自 Yathu Yathu 群组随机试验的结果。

The impact of an innovative community-based peer-led intervention on uptake and coverage of sexual and reproductive health services among adolescents and young people 15-24 years old: results from the Yathu Yathu cluster randomised trial.

机构信息

Zambart, Zambart House, UNZA Ridgeway Campus, off Nationalist Road, Lusaka, Zambia.

Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

出版信息

BMC Public Health. 2024 May 28;24(1):1424. doi: 10.1186/s12889-024-18894-z.


DOI:10.1186/s12889-024-18894-z
PMID:38807091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11134624/
Abstract

BACKGROUND: The Yathu Yathu ("For Us, By Us") cluster-randomized trial (CRT) evaluated a peer-led community-based sexual and reproductive health(SRH) intervention implemented to address persistent barriers to SRH service use among adolescents and young people (AYP). We report the impact of the intervention on coverage of key SRH services among AYP. METHODS: The trial was conducted from Jul 2019-Oct 2021 in two urban communities in Lusaka, Zambia, divided into 20 zones (~ 2350 AYP/zone). Zones were randomly allocated to intervention (N = 10) or control (N = 10) arm. In all zones, a census was conducted and all AYP aged 15-24-years offered participation. The intervention consisted of peer-led community-based hubs providing SRH services; a prevention points card (PPC) system to incentivize and track SRH service use and community engagement. This paper reports on the outcome of coverage (accessing at least one key SRH service), comparing intervention and control arms using PPC data and standard methods of analysis for CRTs. RESULTS: Among enumerated AYP, 93.6% (14,872/15,894) consented to participate from intervention zones and 95.1% (14,500/15,255) from control zones. Among those who accepted a PPC, 63.8% (9,493/14,872) accessed at least one key SRH service during the study period in the intervention arm, compared to 5.4% (776/14,500) in the control arm (adjPR 12.3 95%CI 9.3-16.2, p < 0.001). CONCLUSIONS: The Yathu Yathu intervention increased coverage of key SRH services among AYP and reached two-thirds of AYP. These findings demonstrate the potential of providing peer-led community-based SRH services. TRIAL REGISTRATION: ISRCTN75609016 (11/10/2021), clinicaltrials.gov number NCT04060420 (19/08/2019); retrospectively registered.

摘要

背景:Yathu Yathu(“为我们,由我们”)群组随机对照试验(CRT)评估了一项由同龄人领导的社区性生殖健康(SRH)干预措施,旨在解决青少年和年轻人(AYP)持续存在的 SRH 服务利用障碍。我们报告了该干预措施对 AYP 关键 SRH 服务覆盖范围的影响。

方法:该试验于 2019 年 7 月至 2021 年 10 月在赞比亚卢萨卡的两个城市社区进行,分为 20 个区(~2350 名 AYP/区)。各区随机分配至干预组(N=10)或对照组(N=10)。在所有区,都进行了人口普查,并向所有 15-24 岁的 AYP 提供参与机会。干预措施包括由同龄人领导的社区性中心提供 SRH 服务;预防点卡(PPC)系统,用于激励和跟踪 SRH 服务的使用和社区参与。本文报告了使用 PPC 数据和 CRT 标准分析方法比较干预组和对照组的覆盖范围(获得至少一项关键 SRH 服务)的结果。

结果:在被列举的 AYP 中,93.6%(14872/15894)同意参与干预区的试验,95.1%(14500/15255)同意参与对照组的试验。在接受 PPC 的人中,干预组在研究期间有 63.8%(9493/14872)获得了至少一项关键 SRH 服务,而对照组只有 5.4%(776/14500)(调整后的比值比 12.3,95%置信区间 9.3-16.2,p<0.001)。

结论:Yathu Yathu 干预措施提高了 AYP 关键 SRH 服务的覆盖范围,并覆盖了三分之二的 AYP。这些发现表明,提供由同龄人领导的社区性 SRH 服务具有潜力。

试验注册:ISRCTN75609016(2021 年 11 月 10 日),clinicaltrials.gov 编号 NCT04060420(2019 年 8 月 19 日);回顾性注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b5/11134624/45df7f9d3f0a/12889_2024_18894_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b5/11134624/16d9d9ba21dc/12889_2024_18894_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b5/11134624/45df7f9d3f0a/12889_2024_18894_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b5/11134624/16d9d9ba21dc/12889_2024_18894_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b5/11134624/45df7f9d3f0a/12889_2024_18894_Fig2_HTML.jpg

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本文引用的文献

[1]
The impact of community-based, peer-led sexual and reproductive health services on knowledge of HIV status among adolescents and young people aged 15 to 24 in Lusaka, Zambia: The Yathu Yathu cluster-randomised trial.

PLoS Med. 2023-4

[2]
Healthcare workers' perspectives on access to sexual and reproductive health services in the public, private and private not-for-profit sectors: insights from Kenya, Tanzania, Uganda and Zambia.

BMC Health Serv Res. 2022-7-6

[3]
Adapting community-based sexual and reproductive health services for adolescents and young people aged 15-24 years in response to COVID-19 in Lusaka, Zambia: the implications on the uptake of HIV testing services.

BMC Health Serv Res. 2022-4-14

[4]
Closing the gap: did delivery approaches complementary to home-based testing reach men with HIV testing services during and after the HPTN 071 (PopART) trial in Zambia?

J Int AIDS Soc. 2022-1

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Global, regional, and national mortality among young people aged 10-24 years, 1950-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Lancet. 2021-10-30

[6]
Yathu Yathu ("For us, by us"): Design of a cluster-randomised trial of the impact of community-based, peer-led comprehensive sexual and reproductive health services for adolescents and young people aged 15 to 24 in Lusaka, Zambia.

Contemp Clin Trials. 2021-11

[7]
Engaging young people in the design of a sexual reproductive health intervention: Lessons learnt from the Yathu Yathu ("For us, by us") formative study in Zambia.

BMC Health Serv Res. 2021-7-29

[8]
Factors influencing access to and utilisation of youth-friendly sexual and reproductive health services in sub-Saharan Africa: a systematic review.

Reprod Health. 2021-6-27

[9]
Impact of a community-wide combination HIV prevention intervention on knowledge of HIV status among adolescents.

AIDS. 2021-2-2

[10]
HIV testing and treatment coverage achieved after 4 years across 14 urban and peri-urban communities in Zambia and South Africa: An analysis of findings from the HPTN 071 (PopART) trial.

PLoS Med. 2020-4-2

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