Temerty School of Medicine, University of Toronto, Toronto, ON, Canada.
Dalla Lana School of Public Health and Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
J Cutan Med Surg. 2024 Jul-Aug;28(4):352-359. doi: 10.1177/12034754241253195. Epub 2024 May 28.
Rosacea is a chronic inflammatory skin condition affecting approximately 5.5% of the global population. Patients present heterogeneously with a mix of features in the central facial region, of which papules and pustules are considered to be a major feature. The identification of effective treatments for reducing inflammatory lesions in rosacea can alleviate the psychosocial burden that many rosacea patients experience, including reduced self-esteem, anxiety, and social withdrawal. The objective of this systematic review is to determine the effectiveness of topical and systemic therapies in reducing lesion count in rosacea patients.
METHODS/RESULTS: Medline, Embase, and Cochrane CENTRAL databases were searched, resulting in the inclusion of 43 clinical trials reporting on a total of 18,347 rosacea patients. The most well-studied treatments include ivermectin, metronidazole, azelaic acid, minocycline, and doxycycline. Oral isotretinoin was the most effective treatment in reducing inflammatory lesions and may be recommended for severe recalcitrant cases of rosacea.
Several topical and systemic therapies have demonstrated efficacy in reducing inflammatory lesion count in rosacea patients, with mechanisms of action centred around suppressing inflammation and killing mites. Additional research is required to determine effective combination therapies in rosacea.
酒渣鼻是一种影响全球约 5.5%人口的慢性炎症性皮肤疾病。患者在面部中央区域表现出异质性，伴有多种特征，其中丘疹和脓疱被认为是主要特征。寻找减少酒渣鼻炎症病变的有效治疗方法可以减轻许多酒渣鼻患者所经历的心理社会负担，包括自尊心下降、焦虑和社交退缩。本系统评价的目的是确定局部和全身治疗在减少酒渣鼻患者病变计数方面的有效性。
方法/结果：检索了 Medline、Embase 和 Cochrane CENTRAL 数据库，共纳入了 43 项临床试验，总计纳入了 18347 例酒渣鼻患者。研究最多的治疗方法包括伊维菌素、甲硝唑、壬二酸、米诺环素和多西环素。口服异维 A 酸是减少炎症病变最有效的治疗方法，可能推荐用于严重难治性酒渣鼻病例。
几种局部和全身治疗方法已被证明在减少酒渣鼻患者的炎症病变计数方面有效，其作用机制主要集中在抑制炎症和杀死螨虫上。需要进一步研究以确定酒渣鼻的有效联合治疗方法。
