Di Fede Olga, La Mantia Gaetano, Del Gaizo Carmine, Mauceri Rodolfo, Matranga Domenica, Campisi Giuseppina
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
Unit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility and Continuity of Care, University Hospital Palermo, Palermo, Italy.
Oral Dis. 2024 Nov;30(8):5183-5194. doi: 10.1111/odi.15006. Epub 2024 May 29.
Exodontia is commonly considered as a risk factor for the development of medication-related osteonecrosis of the jaw (MRONJ) in individuals exposed to bone modifying agents. This study was aimed at assessing the efficiency and safety of a gaseous oxygen-ozone mixture as an adjuvant to a standard exodontia to reduce the risk of MRONJ development.
A randomized, open-label, phase II, single-center clinical trial involving 117 patients at risk of MRONJ was conducted. The study protocol tested injections of an oxygen-ozone mixture in the post-extraction site. Participants were randomly assigned to two groups: oxygen-ozone therapy, and standard tooth extraction protocol. Post-extraction wound healing was assessed using the Inflammatory Proliferative Remodeling (IPR) Wound Healing Scale.
The oxygen-ozone therapy group exhibited a significant improvement in wound healing post-extraction during the inflammatory and proliferative phases, as indicated by the IPR scale scores at 3-5 days (p = 0.006) and 14 days (p < 0.001) respectively.
Oxygen-ozone therapy shows promise in improving post-extraction healing in patients at risk of MRONJ. Future studies with larger sample sizes and multicenter collaborations are recommended to confirm the validity of these findings and explore the long-term efficacy of ozone therapy.
在暴露于骨改良剂的个体中，拔牙通常被认为是发生药物相关性颌骨坏死（MRONJ）的一个风险因素。本研究旨在评估气态氧 - 臭氧混合物作为标准拔牙辅助手段以降低MRONJ发生风险的有效性和安全性。
进行了一项随机、开放标签、II期、单中心临床试验，纳入117名有MRONJ风险的患者。研究方案测试了在拔牙后部位注射氧 - 臭氧混合物。参与者被随机分为两组：氧 - 臭氧治疗组和标准拔牙方案组。使用炎症增殖重塑（IPR）伤口愈合量表评估拔牙后伤口愈合情况。
氧 - 臭氧治疗组在拔牙后的炎症期和增殖期伤口愈合有显著改善，分别由IPR量表在3 - 5天（p = 0.006）和14天（p < 0.001）的评分表明。
氧 - 臭氧治疗在改善有MRONJ风险患者的拔牙后愈合方面显示出前景。建议未来进行更大样本量和多中心合作的研究，以确认这些发现的有效性并探索臭氧治疗的长期疗效。
