Karrabi Malihe, Baghani Zahra
Department of Prosthodontics, Faculty of Dentistry, Sabzevar University of Medical Sciences, SabzevarIran.
Department of Periodontics, Faculty of Dentistry, Sabzevar University of Medical Sciences, SabzevarIran.
J Oral Maxillofac Res. 2022 Mar 31;13(1):e2. doi: 10.5037/jomr.2022.13102. eCollection 2022 Jan-Mar.
This systematic review and meta-analysis study sought to review the efficacy of amoxicillin/metronidazole dose and duration time in the treatment of stage II - III grade C periodontitis (aggressive periodontitis) after current follow-up.
An electronic search of the literature was performed in three main databases for relevant articles published until 31 of December 2021. According to the PRISMA statement, the extracted data from selected articles were pooled. The weighted mean difference (MD) and 95% confidence interval (CI) of clinical attachment level (CAL) gain and probing depth (PD) reduction at 3 and 6 months of follow-up were calculated. The heterogeneity of the data was evaluated by the I test.
The results of six randomized clinical trials revealed significant improvement of clinical parameters in moderate and severe pockets. Prescription of 400 to 500 mg metronidazole caused significant CAL gain changes just in moderate pockets (MD = 1.82; 95% CI = 1.11 to 2.53; P < 0.05).
Amoxicillin/metronidazole has positive short-term effects as an adjunct to scaling and root planning for treatment of stage II - III grade C periodontitis. Higher doses of metronidazole (400 to 500 mg) are required for optimal efficacy regarding clinical attachment level gain.
本系统评价和荟萃分析研究旨在回顾阿莫西林/甲硝唑的剂量和疗程对Ⅱ - Ⅲ级C型牙周炎（侵袭性牙周炎）在当前随访后的治疗效果。
在三个主要数据库中进行文献电子检索，查找截至2021年12月31日发表的相关文章。根据PRISMA声明，对所选文章提取的数据进行汇总。计算随访3个月和6个月时临床附着水平（CAL）增加和探诊深度（PD）减少的加权平均差（MD）及95%置信区间（CI）。通过I检验评估数据的异质性。
六项随机临床试验的结果显示，中重度牙周袋的临床参数有显著改善。仅在中度牙周袋中，400至500毫克甲硝唑的处方导致CAL增加有显著变化（MD = 1.82；95% CI = 1.11至2.53；P < 0.05）。
阿莫西林/甲硝唑作为Ⅱ - Ⅲ级C型牙周炎刮治和根面平整治疗的辅助用药具有积极的短期效果。对于临床附着水平增加的最佳疗效，需要更高剂量的甲硝唑（400至500毫克）。
