霍文德西酸A-D：从具有抗癌特性的茎中提取的四种新型ceanothane型三萜类化合物。
Hovendulcisic acid A-D: four novel ceanothane-type triterpenoids from stems with anticancer properties.
作者信息
Yang Jianzhan, Cai Wanna, Wu Fan, Xu Shengmei, Zhang Xiaoqi, Liu Bo, Xu Fangfang
机构信息
Guangdong Provincial Key Laboratory of Research on Emergency in TCM, the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Pharmacy, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
出版信息
Front Chem. 2024 May 14;12:1383886. doi: 10.3389/fchem.2024.1383886. eCollection 2024.
Sixteen ceanothane-type triterpenoids, including four new compounds-hovendulcisic acids A-D (-) -were purified from the stems of Thunb. The structures of - were confirmed by comprehensive means including ECD and quantum chemical calculations. Putative biosynthetic pathways of - were proposed, and , , and exhibited antitumor activity on A549 and MDA-MB-231 cells.
从Thunb.的茎中纯化出16种ceanothane型三萜类化合物，包括4种新化合物——hoven dulcisic acids A - D（-）。通过包括ECD和量子化学计算在内的综合手段确定了它们的结构。提出了它们可能的生物合成途径，并且hoven dulcisic acids A、B、C和D对A549和MDA - MB - 231细胞表现出抗肿瘤活性。
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