人垂体组织中的真性肾素。

True renin in human pituitary tissue.

作者信息

Mizuno K, Ojima M, Gotoh M, Hashimoto S, Fukuchi S

出版信息

J Neurochem. 1985 Feb;44(2):633-6. doi: 10.1111/j.1471-4159.1985.tb05459.x.

DOI:10.1111/j.1471-4159.1985.tb05459.x

Abstract

Readily detectable levels of renin activity were demonstrated in human pituitary tissues. This activity was inhibited by specific antibody raised against human renal renin, indicating that it was not due to the nonspecific action of proteases. It shared some biochemical features with well-known kidney renin, such as molecular weight, optimum pH, and the presence of trypsin-activatable inactive renin. These results suggest that true renin exists in human pituitary tissue.

摘要

在人垂体组织中检测到了易于察觉的肾素活性水平。这种活性被针对人肾肾素产生的特异性抗体所抑制，这表明它并非由蛋白酶的非特异性作用所致。它与知名的肾脏肾素具有一些生化特征，如分子量、最适pH值以及存在可被胰蛋白酶激活的无活性肾素。这些结果表明人垂体组织中存在真正的肾素。