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中链二羧酸：化学、药理特性及其在现代制药和化妆品行业中的应用。

Medium-chain dicarboxylic acids: chemistry, pharmacological properties, and applications in modern pharmaceutical and cosmetics industries.

作者信息

Liao Zhengrui, Yeoh Yu-Kee, Parumasivam Thaigarajan, Koh Wee Yin, Alrosan Mohammad, Alu'datt Muhammad H, Tan Thuan-Chew

机构信息

Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia 11800 USM Penang Malaysia

School of Housing, Building and Planning, Universiti Sains Malaysia 11800 USM Penang Malaysia.

出版信息

RSC Adv. 2024 May 28;14(24):17008-17021. doi: 10.1039/d4ra02598a. eCollection 2024 May 22.

DOI:10.1039/d4ra02598a
PMID:38808239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11130641/
Abstract

Succinic (SUA), glutaric (GLA), pimelic (PA), suberic (SUBA), adipic (ADA), azelaic (AZA), and sebacic acids (SA) make up the majority of medium-chain dicarboxylic acids (MCDAs) with chain lengths of C4-C10, and are widely utilised in the chemical, food, textile, pesticide, pharmaceutical, and liquid crystal sectors. The MCDAs' two carboxyl groups provide them with an incredibly broad variety of applications. The focus of significant scientific research now is on the increasingly varied pharmacological effects of MCDAs. However, only a few studies have compared the biological characteristics of MCDAs in the contemporary pharmaceutical and cosmetic sectors and thoroughly examined the most recent research and marketing initiatives for MCDAs. This review's objective is to offer a thorough analysis of academic works on MCDAs, to assess the usefulness of these substances' chemical-pharmacological properties for use in the contemporary pharmaceutical and cosmetic industries, and to investigate the direction of their possible applications in these two disciplines. In addition, this review investigates how these compounds are metabolised in the human body.

摘要

琥珀酸（SUA）、戊二酸（GLA）、庚二酸（PA）、辛二酸（SUBA）、己二酸（ADA）、壬二酸（AZA）和癸二酸（SA）构成了链长为C4 - C10的中链二元羧酸（MCDA）的大部分，并且广泛应用于化学、食品、纺织、农药、制药和液晶领域。MCDA的两个羧基赋予了它们极其广泛的应用。目前重要的科学研究重点是MCDA日益多样的药理作用。然而，在当代制药和化妆品领域，只有少数研究比较了MCDA的生物学特性，并全面审视了MCDA的最新研究和市场推广举措。本综述的目的是对关于MCDA的学术著作进行全面分析，评估这些物质化学药理特性在当代制药和化妆品行业中的实用性，并探讨它们在这两个学科中可能的应用方向。此外，本综述还研究了这些化合物在人体中的代谢方式。

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