Rafeey Mandana, Ghergherehchi Robabeh, Nikniaz Zeinab, Shoaran Maryam, Hosseinalizadeh Amaneh
Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pediatric Endocrinology Department, Children Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Biomed Res. 2024 Apr 27;13:25. doi: 10.4103/abr.abr_247_21. eCollection 2024.
Celiac disease is popular and needs a proper and constant gluten-free diet. However, data on the experience of the disease by children are insufficient. A few children have difficulty adjusting their lifestyles, and gluten-free foods are difficult for them. The present study aimed to find influential factors in the growth disorders and nonresponse to the treatment diet in celiac patients.
We gave a list of all children with celiac disease to the project manager and according to the criteria extracted additional information from their files. Duodenal biopsies on 382 patients with suspected celiac disease and 93 patients with positive pathology were included in the study, regardless of antibody and genetic titer, then analyzed their information using appropriate statistical tests.
The mean age of individuals was 9.48 ± 3.88, and 35 were male and 58 female. At the age of <5, there was more growth disorder than other age groups. The recovery percentage in short stature was significantly better in children with higher marches, and they responded better to the treatment regimen. Individuals with comorbidities had higher anti-tTG and lower Hb levels, higher incidence of growth disorder, did not respond to the treatment regimen. Those with a first-degree relative with celiac disease had a lower growth disorder than others.
Identifying and correcting nutritional disorders in patients with celiac disease need to evaluate persistent symptoms and identify their causes to plan appropriate treatment and follow-up of patients with celiac disease step by step and continuously.
乳糜泻很常见,需要适当且持续的无麸质饮食。然而,关于儿童患该病经历的数据并不充分。一些儿童在调整生活方式方面存在困难,无麸质食物对他们来说也很困难。本研究旨在找出乳糜泻患者生长障碍及对治疗饮食无反应的影响因素。
我们将所有乳糜泻患儿名单交给项目经理,并根据标准从他们的病历中提取额外信息。本研究纳入了382例疑似乳糜泻患者和93例病理检查呈阳性患者的十二指肠活检样本,无论抗体和基因滴度如何,然后使用适当的统计检验分析他们的信息。
研究对象的平均年龄为9.48±3.88岁,男性35例,女性58例。5岁以下儿童的生长障碍比其他年龄组更多。身高较矮的儿童中,进展较高的儿童恢复百分比明显更好,且他们对治疗方案的反应更好。患有合并症的个体抗组织转谷氨酰胺酶(anti-tTG)水平较高、血红蛋白(Hb)水平较低、生长障碍发生率较高,对治疗方案无反应。有乳糜泻一级亲属的个体生长障碍比其他人少。
识别和纠正乳糜泻患者的营养紊乱需要评估持续症状并找出其原因,以便逐步且持续地为乳糜泻患者制定合适的治疗和随访计划。