Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.
World J Gastroenterol. 2021 May 21;27(19):2251-2256. doi: 10.3748/wjg.v27.i19.2251.
Celiac Disease (CD) had been considered uncommon in Asia for a long time. However, several studies suggested that, in the Indian subcontinent and Middle East countries, CD is present and as prevalent as in Western countries. Outside these Asian regions, the information about the epidemiology of CD is still lacking or largely incomplete for different and variable reasons. Here, we discuss the epidemiological aspects and the diagnostic barriers in several Asian regions including China, Japan, Southeast Asia and Russia/Central Asia. In some of those regions, especially Russia and Central Asia, the prevalence of CD is very likely to be underestimated. Several factors may, to a different extent, contribute to CD underdiagnosis (and, thus, underestimation of its epidemiological burden), including the poor disease awareness among physicians and/or patients, limited access to diagnostic resources, inappropriate use or interpretation of the serological tests, absence of standardized diagnostic and endoscopic protocols, and insufficient expertise in histopathological interpretation.
很长一段时间以来，人们一直认为亚洲的乳糜泻（CD）病例较少。然而，有几项研究表明，在印度次大陆和中东国家，CD 也存在，其发病率与西方国家相当。在这些亚洲地区以外，由于各种不同的原因，有关 CD 流行病学的信息仍然缺乏或极不完整。在这里，我们讨论了包括中国、日本、东南亚和俄罗斯/中亚在内的几个亚洲地区的流行病学方面和诊断障碍。在这些地区中的一些地区，特别是俄罗斯和中亚，CD 的患病率很可能被低估。有几个因素可能在不同程度上导致 CD 的漏诊（因此，低估了其流行病学负担），包括医生和/或患者对疾病认识不足、诊断资源有限、对血清学检测的不当使用或解释、缺乏标准化的诊断和内镜检查方案，以及在组织病理学解释方面的专业知识不足。
