Hota Sudhir Kumar, Singh Gulshan, Murarka Sandip
Department of Chemistry, Indian Institute of Technology Jodhpur, Karwar-342037, Rajasthan, India.
Chem Commun (Camb). 2024 Jun 13;60(49):6268-6271. doi: 10.1039/d4cc01837k.
We present an organophotoredox-catalyzed direct Csp-H alkylation of 3,4-dihydroquinoxalin-2-ones employing -(acyloxy)pthalimides to provide corresponding products in good yields. A broad spectrum of NHPI esters (1°, 2°, 3°, and sterically encumbered) participates in the photoinduced alkylation of a variety of 3,4-dihydroquinoxalin-2-ones. In general, mild conditions, broad scope with good functional group tolerance, and scalability are the salient features of this direct alkylation process.
我们报道了一种有机光氧化还原催化的3,4-二氢喹喔啉-2-酮的直接Csp-H烷基化反应，该反应使用-(酰氧基)邻苯二甲酰亚胺以良好的产率提供相应产物。多种NHPI酯（伯、仲、叔以及空间位阻较大的）参与了各种3,4-二氢喹喔啉-2-酮的光诱导烷基化反应。一般来说，温和的条件、对官能团具有广泛耐受性的底物范围以及可扩展性是这种直接烷基化过程的显著特点。
