[Analysis of risk factors associated with postoperative pancreatic fistula after robotic-assisted distal pancreatectomy].

To investigate pertinent risk factors for postoperative pancreatic fistula(POPF) after robotic-assisted distal pancreatectomy(RDP). This is a retrospective cohort study. Clinical data of 1 211 patients who underwent various methods of distal pancreatectomy at the Department of General Surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,between January 2021 and December 2023 were retrospectively collected. Among the 1 211 patients,440 cases were in the robot-assisted group(173 males and 267 females),with an age((IQR)) of 55(29)years;720 cases were in the open surgery group (390 males and 330 females),with an age of 64(15)years;and 51 cases were in the laparoscopic group(17 males and 34 females),with an age of 56(25)years. These 440 patients who underwent RDP were divided into two cohorts based on the presence of clinically relevant pancreatic fistulas(grades B and C). Univariate and multivariate analysis were performed on 27 factors related to POPF. Univariate analysis methods included independent sample -test,Mann-Whitney test,and test,while multivariate analysis utilized binary logistic regression. After stratification by pathological type,there was no significant difference in the incidence of pancreatic fistula between the robot-assisted group and the open surgery group(benign tumor:=1.200,=0.952;malignant tumor:=0.391,=0.532). The surgical duration of the RDP group (=15.113,<0.01; =4.232, <0.01) was significantly shorter than that of the open surgery and laparoscopic groups,so as the intraoperative blood loss (=12.530,<0.01;=2.550,=0.032). Postoperative hospital stay in the RDP group was significantly shorter than that in the open surgery group (=10.947, <0.01), but not different from that in the laparoscopic group (>0.05). All 440 patients underwent successful surgery,of which there was only 1 case who underwent a conversion to open surgery. A total of 104 patients(23.6%) developed clinically relevant pancreatic fistulas,and no perioperative mortality was observed. Univariate analysis revealed that 6 factors were associated with POPF after RDP: gender(=12.048,=0.001),history of smoking (=6.327,=0.012),history of alcohol consumption (=17.597,<0.01),manual pancreas division (=9.839,=0.002),early elevation of amylase in drainage fluid (=5.187,<0.01),and delayed gastric emptying (=4.485,=0.034). No statistically significant association with POPF was found for the remaining factors(all >0.05).The cut-off value for the early amylase level in the drainage fluid was determined to be 7 719.5 IU/ml,with an area under curve of 0.676 determined by receiver operating characteristic curve analysis. Binary logistic regression analysis identified a history of alcohol consumption(=0.002,95%: 0.112 to 0.623), manual pancreas division(=0.001,95%:1.446 to 4.082),early amylase level of drainage fluid ≥7 719.5 IU/ml(<0.01,95%:0.151 to 0.438),and delayed gastric emptying (=0.020, 95%: 1.131 to 4.233) as independent risk factors for POPF of RDP. Patients with pancreatic body and tail tumors who receive RDP therapy are at increased risk of developing a pancreatic fistula if they have a history of alcohol consumption,manual pancreas division,early elevation of amylase in drainage fluid to ≥7 719.5 IU/ml, or delayed gastric emptying.