Zunyi Medical and Pharmaceutical College, Guizhou, 563006, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100029, China.
J Nat Med. 2024 Sep;78(4):985-994. doi: 10.1007/s11418-024-01813-2. Epub 2024 May 29.
Inflammation and apoptosis are common in many pathological conditions. Studies have shown that many natural compounds can regulate the signal pathways related to inflammation and apoptosis and can prevent sepsis-associated acute kidney injury (SA-AKI). Several studies have reported the potential anti-inflammatory effect of byakangelicin (BK), a component from the roots of Angelica gigas. However, the role of BK in SA-AKI remains unknown. Here, we report that BK is a potential therapeutic drug for SA-AKI. Experimental results show that BK has high anti-inflammatory activity, inhibits the activation of the NF-κB signaling pathway, and then reduces the production of IL-6, TNF-a, and IFN-γ. In addition, we study the effect of BK on renal cell apoptosis and find that BK significantly reduces the expression of apoptosis-related genes. Further research suggests that BK may exert the above pharmacological effects through 26S protease regulatory subunit 8 (PSMC5). These findings indicate that BK, as an inhibitor of inflammation and apoptosis, can be used to treat SA-AKI.
炎症和细胞凋亡在许多病理条件下很常见。研究表明，许多天然化合物可以调节与炎症和细胞凋亡相关的信号通路，从而预防脓毒症相关的急性肾损伤（SA-AKI）。几项研究报告了当归素（BK）的潜在抗炎作用，BK 是当归根的一种成分。然而，BK 在 SA-AKI 中的作用尚不清楚。在这里，我们报告 BK 是治疗 SA-AKI 的一种潜在治疗药物。实验结果表明，BK 具有很强的抗炎活性，抑制 NF-κB 信号通路的激活，从而减少 IL-6、TNF-a 和 IFN-γ的产生。此外，我们研究了 BK 对肾细胞凋亡的影响，发现 BK 显著降低了与凋亡相关的基因表达。进一步的研究表明，BK 可能通过 26S 蛋白酶调节亚基 8（PSMC5）发挥上述药理作用。这些发现表明，BK 作为一种炎症和细胞凋亡抑制剂，可用于治疗 SA-AKI。
