Romero R, Cullen M, Grannum P, Jeanty P, Reece E A, Venus I, Hobbins J C
Am J Obstet Gynecol. 1985 Jan 1;151(1):38-43. doi: 10.1016/0002-9378(85)90420-x.
Bilateral renal agenesis is a lethal congenital anomaly. A reliable prenatal diagnosis is extremely important, since it may offer options for pregnancy termination or may change obstetric management in the third trimester. This study examined the accuracy of ultrasound in making an antenatal diagnosis of bilateral renal agenesis in three different populations: (1) patients with a family history of bilateral renal agenesis, (2) patients diagnosed during the course of a routine scan, and (3) patients referred because of a previous suspicious ultrasound examination in a level I ultrasound facility. In group A there were three true positive, 13 true negative, no false negative, and no false positive diagnoses. In group B there were three true positive and no false positive diagnoses. In group C there were 12 true positive, 17 true negative, one false negative, and no false positive diagnoses. The value and potential pitfall of the different diagnostic criteria are discussed. We conclude that ultrasound is a valuable tool in the detection of intrauterine renal failure, although there are limitations to a specific diagnosis of bilateral renal agenesis.
双侧肾缺如是一种致命的先天性异常。可靠的产前诊断极其重要，因为它可能为终止妊娠提供选择，或者可能改变孕晚期的产科管理。本研究在三种不同人群中检验了超声产前诊断双侧肾缺如的准确性：（1）有双侧肾缺如家族史的患者；（2）在常规扫描过程中被诊断出的患者；（3）因之前在一级超声机构进行的超声检查可疑而被转诊的患者。A组有3例假阳性、13例假阴性、无假阴性和无假阳性诊断。B组有3例假阳性且无假阳性诊断。C组有12例假阳性、17例假阴性、1例假阴性和无假阳性诊断。讨论了不同诊断标准的价值和潜在陷阱。我们得出结论，超声是检测宫内肾衰竭的一种有价值的工具，尽管对双侧肾缺如进行特异性诊断存在局限性。
