INSERM UMR 1105, Research Group on Multimodal Analysis of Brain Function, University of Picardie Jules Verne, rue René Laennec, 80054 Amiens Cedex, France; Pediatric Neurophysiology Unit, Amiens-Picardie University Hospital, 1 rue du Professeur Christian Cabrol, 80054 Amiens Cedex, France.
INSERM UMR 1105, Research Group on Multimodal Analysis of Brain Function, University of Picardie Jules Verne, rue René Laennec, 80054 Amiens Cedex, France.
Clin Neurophysiol. 2024 Jul;163:236-243. doi: 10.1016/j.clinph.2024.04.006. Epub 2024 Apr 17.
To characterize Negative Central Activity (NCA), an overlooked electroencephalographic activity of preterm newborns and investigate its relationship with brain injuries, dysfunction, and neurodevelopmental outcome.
109 preterm infants (23-28 weeks) were retrospectively included. NCA were selected at the negative peak on EEG. Individual averaged NCA were automatically characterized. Brain structural data were collected from cranial ultrasounds (cUS). The neurodevelopmental outcome at two years of age was assessed by the Denver Developmental Screening Test-II.
Thirty-six (33%) children showed NCA: 6,721 NCA were selected, a median of 75 (interquartile range, 25/157.3) per EEG. NCA showed a triphasic morphology, with a mean amplitude and duration of the negative component of 24.6-40.0 µV and 222.7-257.3 ms. The presence of NCA on EEG was associated with higher intraventricular haemorrhage (IVH) grade on the first (P = 0.016) and worst neonatal cUS (P < 0.001) and poorer neurodevelopmental outcome (P < 0.001).
NCA is an abnormal EEG feature of extremely preterm newborns that may correspond to the functional neural impact of a vascular pathology.
The NCA relationships with an adverse outcome and the presence/severity of IVH argue for considering NCA in the assessment of pathological processes in the developing brain network and for early outcome prediction.
描述负中央活动（NCA），这是一种被忽视的早产儿脑电图活动，并研究其与脑损伤、功能障碍和神经发育结局的关系。
回顾性纳入 109 例早产儿（23-28 周）。在脑电图上选择负峰处的 NCA。自动对个体平均 NCA 进行特征描述。从头颅超声（cUS）中收集脑结构数据。通过丹佛发育筛查测试 II 评估 2 岁时的神经发育结局。
36 名（33%）儿童出现 NCA：共选择了 6721 个 NCA，每个脑电图的中位数为 75（四分位距 25/157.3）。NCA 呈三相形态，负成分的平均幅度和持续时间为 24.6-40.0μV 和 222.7-257.3ms。脑电图上存在 NCA 与首次（P=0.016）和最差新生儿 cUS（P<0.001）更高的脑室内出血（IVH）分级以及更差的神经发育结局（P<0.001）相关。
NCA 是极早产儿脑电图的异常特征，可能与血管病变的功能神经影响相对应。
NCA 与不良结局以及 IVH 的存在/严重程度之间的关系表明，在评估发育中脑网络的病理过程和早期预后预测时，应考虑 NCA。
