Lipschitz D A, Goldstein S, Reis R, Weksler M E, Bressler R, Neilan B A
Ann Intern Med. 1985 Feb;102(2):218-28. doi: 10.7326/0003-4819-102-2-218.
The incidence of cancer increases progressively with age. Rearrangements of genomes have been found to accompany cellular aging. These factors, in concert with age-dependent alterations in immune function and host defense, may help to explain the increased risk of malignant disease in aged persons. The clinical presentation and natural history of neoplasia are also affected by aging. This conference reviews recent developments in these areas, examines the effects of drug use in the elderly and implications for management, and discusses current information on how age may influence the response of cancer to therapy.
癌症的发病率随年龄增长而逐渐上升。已发现基因组重排与细胞衰老相伴发生。这些因素，再加上免疫功能和宿主防御方面的年龄依赖性改变，可能有助于解释老年人患恶性疾病风险增加的原因。肿瘤形成的临床表现和自然病程也受到衰老的影响。本次会议回顾了这些领域的最新进展，研究了老年人用药的影响及其对治疗的意义，并讨论了关于年龄如何影响癌症对治疗反应的现有信息。
