Misra Debashish, Seo Pearl H, Cohen Harvey Jay
Department of Medicine, Division of Geriatrics, Duke University Medical Center, Durham, NC 27710, USA.
Clin Adv Hematol Oncol. 2004 Jul;2(7):457-65.
A substantial increase in the number of elderly people in the populations of developed nations in the coming years has been projected. Persons 65 years and older are at significantly higher risk of developing cancer when compared to younger individuals. There is a resulting increase in cancer incidence as well as mortality in this advanced age group. It is important to know how changes in physiological reserve and functional status in elderly patients, polypharmacy issues, comorbidities, and other age-related problems can affect cancer prognosis and management. Elderly patients are not adequately represented in clinical trials, thus creating a relative lack of information related to specific issues about elderly cancer patients and their care. Nevertheless, there is a substantial amount of guidance available, and in this review we will address selected issues of importance when considering the approach to the older cancer patient.
预计在未来几年，发达国家人口中老年人数量将大幅增加。与年轻人相比，65岁及以上的人群患癌症的风险显著更高。这导致该老年人群体的癌症发病率和死亡率上升。了解老年患者生理储备和功能状态的变化、多重用药问题、合并症以及其他与年龄相关的问题如何影响癌症的预后和治疗很重要。老年患者在临床试验中的代表性不足，因此相对缺乏与老年癌症患者及其护理的具体问题相关的信息。尽管如此，还是有大量可用的指导意见，在本综述中，我们将探讨在考虑老年癌症患者的治疗方法时一些重要的特定问题。
