Department of Neurosurgery and Moyamoya Center, University of Tübingen, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.
Moyamoya Center, University Children's Hospital of Zurich, University of Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland.
Sci Rep. 2024 May 29;14(1):12364. doi: 10.1038/s41598-024-61966-8.
Moyamoya disease (MMD) is a rare stenoocclusive cerebral vasculopathy often treated by neurosurgical revascularization using extracranial-intracranial bypasses to prevent ischemic or hemorrhagic events. Little is known about the vascular risk profile of adult MMD patients compared to the general population. We therefore analyzed 133 adult MMD patients and compared them with data from more than 22,000 patients from the German Health Update database. Patients with MMD showed an age- and sex-adjusted increased prevalence of arterial hypertension, especially in women between 30 and 44 years and in patients of both sexes between 45 and 64 years. Diabetes mellitus was diagnosed significantly more frequently in MMD patients with increasing age, whereas the vascular risk profile in terms of obesity, nicotine and alcohol consumption was similar to that of the general population. Antihypertensive medication was changed one year after surgical revascularization in 67.5% of patients with a tendency towards dose reduction in 43.2% of all patients. After revascularization, physicians need to be aware of a high likelihood of changes in arterial hypertension and should adjust all other modifiable systemic vascular risk factors to achieve the best treatment possible.
烟雾病（MMD）是一种罕见的颅底动脉狭窄或闭塞性脑血管疾病，常通过颅内外搭桥手术进行血运重建，以预防缺血性或出血性事件。与普通人群相比，关于成年 MMD 患者的血管风险概况知之甚少。因此，我们分析了 133 名成年 MMD 患者，并将其与来自德国健康更新数据库的超过 22000 名患者的数据进行了比较。与对照组相比，MMD 患者存在年龄和性别调整后的高血压患病率增加，尤其是 30-44 岁的女性和 45-64 岁的男性。随着年龄的增长，MMD 患者被诊断出糖尿病的频率显著增加，而在肥胖、尼古丁和酒精摄入方面，其血管风险状况与普通人群相似。在接受手术血运重建的患者中，有 67.5%的患者在术后一年改变了降压药物，所有患者中有 43.2%的患者有降低剂量的趋势。在血运重建后，医生需要注意高血压发生变化的可能性很大，应调整所有其他可改变的系统性血管危险因素，以达到最佳治疗效果。
