Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, Zhejiang, China.
Department of Prosthodontics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, Hangzhou, 310006, Zhejiang, China.
BMC Oral Health. 2024 May 29;24(1):634. doi: 10.1186/s12903-024-04184-y.
The aim of this study was to assess the outcomes of the combination technique of strip free gingival grafts (SFGG) and xenogeneic collagen matrix (XCM) in augmenting the width of keratinized mucosa (KMW) around dental implants, and compare its efficacy with the historical control group (FGG).
Thirteen patients with at least one site with KMW ≤ 2 mm after implant surgery were included and received SFGG in combination with XCM. Another thirteen patients with the same inclusion and exclusion criteria from the previous trial received FGG alone. The same outcomes as the previous trial were evaluated. KMW, thickness of keratinized mucosa (KMT), gingival index (GI) and probing depth (PD) were measured at baseline, 2 and 6 months. Postoperative pain, patient satisfaction and aesthetic outcomes were also assessed.
At 6 months after surgery, the combination technique could attain 3.3 ± 1.6 mm of KMW. No significant change could be detected in GI or PD at 6 months compared to those at 2 months (p > 0.05). The postoperative pain and patient satisfaction in VAS were 2.6 ± 1.2 and 9.5 ± 1.2. The total score of aesthetic outcomes was 3.8 ± 1.2. In the historical FGG group, 4.6 ± 1.6 mm of KMW was reported at 6 months, and the total score of aesthetic outcomes was higher than the combination technique (4.8 ± 0.7 vs. 3.8 ± 1.2, p < 0.05).
The combination technique of SFGG and XCM could increase KMW and maintain peri-implant health. However, this combination technique was associated with inferior augmentation and aesthetic outcomes compared with FGG alone.
This clinical trial was registered in the Chinese Clinical Trial Registry with registration number ChiCTR2200057670 on 15/03/2022.
本研究旨在评估条状游离龈移植（SFGG）联合异种胶原基质（XCM）技术在增加种植体周围角化黏膜（KMW）宽度方面的效果，并与历史对照组（FGG）进行比较。
共纳入 13 名种植术后至少有一个位点角化黏膜宽度（KMW）≤2mm 的患者，采用 SFGG 联合 XCM 技术。另有 13 名具有相同纳入和排除标准的患者来自之前的试验，仅接受 FGG 治疗。评估了与之前试验相同的结果。在基线、2 个月和 6 个月时测量 KMW、角化黏膜厚度（KMT）、牙龈指数（GI）和探诊深度（PD）。还评估了术后疼痛、患者满意度和美学效果。
术后 6 个月，联合技术可获得 3.3±1.6mm 的 KMW。与 2 个月相比，6 个月时 GI 或 PD 无显著变化（p>0.05）。VAS 中的术后疼痛和患者满意度分别为 2.6±1.2 和 9.5±1.2。美学效果的总分为 3.8±1.2。在历史 FGG 组中，6 个月时报告了 4.6±1.6mm 的 KMW，美学效果的总评分高于联合技术（4.8±0.7 与 3.8±1.2，p<0.05）。
SFGG 联合 XCM 技术可增加 KMW 并维持种植体周围健康。然而，与单独使用 FGG 相比，这种联合技术与较差的增加和美学效果相关。
本临床试验于 2022 年 3 月 15 日在中国临床试验注册中心注册，注册号为 ChiCTR2200057670。
