Department of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Institute for Biostatistics, Hannover Medical School, Hannover, Germany.
Clin Oral Implants Res. 2019 May;30(5):457-465. doi: 10.1111/clr.13432. Epub 2019 Apr 25.
This is a cross-sectional study designed with the aim to assess associations between the width of keratinized tissue and peri-implant mucositis.
Two hundred and thirty one dental implants in 52 patients were evaluated. The width of keratinized mucosa (KM), plaque index (mPI), gingival index (mGI), bleeding on probing index (BoP), and the probing depth (PD) were measured clinically. Reduced KM was defined as a width of KM below 2 mm and 1 mm, respectively. In the primary analysis, data were analyzed on the implant level with the help of a generalized estimating equations (GEE) model. In sensitivity analyses, an adjusted linear mixed model was performed.
Forty four implants in 12 patients had less than 2 mm KM, and 187 implants in 40 patients had ≥ 2 mm KM. In the non-adjusted analysis on the implant level, reduced keratinized tissue width was significantly associated with peri-implant mucositis (OR 3.3, 95%-CI (1.3-8.0), p = 0.009) and severity of disease (mean difference 2.5, 95%-CI (0.8-4.2) p = 0.004). In sensitivity analyses, reduced keratinized tissue showed a significant association with severity of disease (OR 1.7, 95%-confidence interval = 0.1-34, p = 0.040).
A reduced width of keratinized tissue around dental implants is a risk indicator for severity of peri-implant mucositis. The overall tendency of the results indicates that a sufficient amount of KM may contribute to reduce risk for and severity of peri-implant mucositis.
本研究为横断面研究,旨在评估角化组织宽度与种植体周围黏膜炎的相关性。
共评估了 52 名患者的 231 个种植体。临床测量角化黏膜宽度(KM)、菌斑指数(mPI)、龈炎指数(mGI)、探诊出血指数(BoP)和探诊深度(PD)。KM 减少定义为 KM 宽度分别小于 2mm 和 1mm。在主要分析中,采用广义估计方程(GEE)模型对种植体水平的数据进行分析。在敏感性分析中,进行了调整后的线性混合模型分析。
12 名患者的 44 个种植体的 KM 小于 2mm,40 名患者的 187 个种植体的 KM 大于等于 2mm。在种植体水平的非调整分析中,角化组织宽度减少与种植体周围黏膜炎显著相关(OR 3.3,95%CI(1.3-8.0),p=0.009)和疾病严重程度(平均差值 2.5,95%CI(0.8-4.2),p=0.004)。在敏感性分析中,角化组织减少与疾病严重程度呈显著相关(OR 1.7,95%置信区间 0.1-34,p=0.040)。
角化组织宽度减少是种植体周围黏膜炎严重程度的危险因素。研究结果的总体趋势表明,足够的 KM 可能有助于降低种植体周围黏膜炎的风险和严重程度。